Dynamics of phagocytic activity of neutrophils in rats under oxidative stress and the action of liposomal preparation
Journal Title: Біологія тварин - Year 2017, Vol 19, Issue 1
Abstract
The article deals with the researches results of the developed complex liposomal preparation influence on dynamics of nonspecific level of natural resistance in rats under modeled oxidative stress caused with the use of carbon tetrachloride. It is proved that intramuscular injection to rats in the experimental group 50 % of oil solution of tetra chloromethane at a dose of 0.25 ml per 100 g of animal body weight determines the antigenic load on the body and causes nonspecific inhibition level of natural resistance. This is indicated with decrease in phagocytic activity of neutrophilsin the blood of infected animals during the entire research period. On the 14th day the indices of phagocyte activity of neutrophils was 42.6 % against 48.9 % in the control group of animals. Alongside with this reduction of values it was found phagocyte index and phagocyte number of blood among rats on the 2nd, 5th and 10thday of research. On the 14th day of the experiment, these indicators in biological object of rat blood of the 1st experimental group were low: accordingly, the value of phagocyte index by 38 % and phagocyte number — 18 % from indicators of the rat organism by oxidative stress. It is advisable to apply the liposomal preparation containing butafosfan, interferon, milk thistle and vitamins. After using liposomal preparation to rats, under oxidative stress during researches, equilibrium level of nonspecific natural resistance is restored in the blood, namely no abnormal parameters of phagocyte activity of neutrophils, phagocyte index and phagocyte number of blood. On the 14th day of experiment the indices of nonspecific link of the immune system in the blood of rats varied within the physiological limits.
Authors and Affiliations
M. Khariv, B. Gutyj
Keywords
Related Articles
- EP ID EP262639
- DOI 10.15407/animbiol19.01.119
- Views 151
- Downloads 0
Water quality considerations for the culture of tropical edible frog (Hoplobatrachus occipitalis) from tadpole stage to full metamorphosis
Good water quality is necessary for artificial cultivation of frogs. There has not been a recommended value for water quality in frog culture. This study was undertaken to determine the ranges of some water quality para...
The influence of genotype on reproductive ability of animals
Ukrainian Black Spotted Dairy breed for a long period was formed and improved through the use of Holstein bulls-sires, leading to an increase in the animal genotype of heredity proportion of improved breed. Research has...
Influence of typological features of autonomous tone on morphometric parameters of goblet cells of chickens’ intestinal mucosa
In adult chickens cross “Iza-Braun”, which were grown in conditions of poultry farms and were selected on the basis of analogues, there are two types of autonomous tone: sympathotonic (CT) — 16 specimen and sympatho-norm...
Biochemical markers of the functional liver state in rats with toxic hepatitis under the conditions of germanium citrate administration
Activity of rats’ liver marker enzymes under the conditions of acetaminophen-induced toxic liver injury and influence of germanium citrate was studied. Hepatitis was modeled in these rats by per os acetaminophen administ...
Effect of fat content in cows diet and pH of rumen on ruminal fermentation and fatty acid composition of milk fat
For the experiment four groups of Ukrainian black and white dairy cows with average milk yield 6000 kg per lactation were used with five animals in each group. The duration of the experiment was from the last month of pr...