Dysfunction of the vascular endothelium in children with acute lymphoblastic leukemia
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2008, Vol 25, Issue 6
Abstract
OBJECTIVE The aim of this study was to determine the levels of the activation markers of the vascular endothelium and coagulation pathway parameters in children with acute lymphoblastic leukemia (ALL), and to compare the results with known prognostic factors and disease outcome, targeting their possible prognostic value. METHOD Fifty two children with ALL, 19 with ALL 1-10 years out of therapy, and 28 healthy children were studied. In all the patients and children of both control groups the following laboratory parameters were determined: (a) coagulation system: platelet number, prothrombin time, partial thromboplastin time, thrombin time, fibrinogen, von Willebrand factor (vWF), antithrombin ΙΙΙ, protein C, protein S, activated protein C resistance, α2-macroglobulin, thrombomodulin (TM), tissue-plasminogen activator, plasminogen activator inhibitor, plasminogen, α2-antiplasmin, D-dimers, and (b) endothelial factors: sP-selectin, vascular cell adhesion molecule-1, β2-integrins, nitric oxide, endothelin-1, platelet derived growth factor. RESULTS-CONCLUSIONS Statistical analysis of the data and consideration of the results led to the following conclusions: In children with ALL, the significant increase of TM and vWF levels observed in the acute phase of the disease and during treatment confirms the serious dysfunction of the vascular endothelium, resulting from the disease itself. The significantly positive correlation of TM, vWF with the leucocyte count before treatment, and the high levels of TM in children with unfavorable outcome, possibly identify these factors as useful predictors in childhood ALL. The findings of the study also suggest the presence of a "hypercoagulable state", often subclinical, during the acute phase of ALL, while abnormal findings in remission possibly result from treatment.
Authors and Affiliations
E. HATZIPANTELIS, M. ATHANASIOU-METAXA, V. TZIMOULI, A. TAPARKOU, N. GOMBAKIS, T. PAPAGEORGIOU, D. KLETA, H. TSANTALI, F. ATHANASIADOU-PIPEROPOULOU
Keywords
Related Articles
- EP ID EP123797
- DOI -
- Views 63
- Downloads 0
Hearing loss among Greek army recruits: A reason to worry
No abstract available
Three-year antibiotic stewardship in a Greek maternity hospital
OBJECTIVE Antibiotic use monitoring is essential for implementing a guided antibiotic policy. In this maternity hospital an antimicrobial stewardship programme was initiated in order to upgrade the high standard of care,...
Αντιλήψεις και απαιτήσεις νοσοκομειακών γιατρών<br /> διαφόρων ειδικοτήτων του λεκανοπεδίου Αττικής<br /> για την ποιότητα παροχής οδοντιατρικής περίθαλψης
ΣΚΟΠΟΣ Στόχος της μελέτης ήταν η διερεύνηση των αντιλήψεων και των απαιτήσεων νοσοκομειακών γιατρών του λεκανοπεδίου Αττικής για την παρεχόμενη οδοντιατρική περίθαλψη, καθώς και των κριτηρίων που τίθενται για την επιλογή...
Pancreaticopleural fistula: From diagnosis to treatment
Pancreaticopleural fistula is an uncommon but severe complication of acute, or more often chronic, pancreatitis, characterized by communication between the pleural cavity (usually the left side) and the pancreatic duct....
The administration of mannitol
No abstract available