DYSLIPIDAEMIA IN CKD PATIENTS AND ITS CORRELATION WITH SEVERITY OF RENAL DYSFUNCTION
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 11
Abstract
BACKGROUND Chronic kidney disease (CKD) is a significant global health problem with significant morbidity and mortality. Dyslipidaemia along with an abnormal apolipoprotein profile and composition is a common complication associated with the decline in eGFR in CKD. The association between abnormal lipid profile and severity of CKD has rarely been studied in a general population, especially in Indian setup and may have a future prognostic and management implication in patients with CKD. Aims and Objectives- To study the pattern of lipid abnormalities in CKD patients and to correlate with severity of renal dysfunction. MATERIALS AND METHODS A descriptive comparative study was done using 50 cases of CKD of > 15 years age, along with 30 age and sex matched controls excluding confounding factors like diabetes, HTN, thyroid abnormalities, heart diseases, infection, inflammatory diseases, smoking, alcoholism etc. History, general and systemic examination, routine blood parameters, ECG, USG abdomen pelvis, serum total cholesterol, LDL, HDL, VLDL and triglycerides were done. The eGFR was calculated according to the CKD-EPI equation. Statistical analysis was done using student’s t-test, ANOVA, Bonferroni test, Mann-Whitney U test, Chi-square test and Pearson’s correlation. P value < 0.05 was considered as statistically significant. RESULTS The lipid profile in cases were TC: 184.96 ± 24.85 mg/dL; TGL: 148.10 ± 32.71 mg/dL; HDL: 32.38 ± 5.78 mg/dL; LDL: 122.82 ± 24.76 mg/dL; VLDL: 29.68 ± 6.54 mg/dL. Correlation between eGFR shows a significant negative correlation with TC (p= 0.007), TGL (p= 0.002), LDL (p= 0.000) and VLDL (p= 0.002) and positive correlation with HDL (p= 0.000). Comparison of lipid profile with grades of eGFR shows significant association with TGL (f= 3.804, p= 0.004), HDL (f= 18.099, p= 0.000), LDL (f= 3.793, p=0.004) and VLDL (f= 3.631, p= 0.005), but not with TC (f= 2.194, p= 0.064). CONCLUSION In CKD depending on severity there is a rise in TC, TGL, LDL, VLDL and a fall in HDL depending on severity
Authors and Affiliations
Rina Mohanty, Ritesh Acharya, Pravat Kumar Thatoi, Hrudananda Bhuyan, Satarupa Mohapatra, Satyabrata Sahoo
Keywords
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- EP ID EP411597
- DOI 10.14260/jemds/2018/301
- Views 84
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