Early diagnostics and incidence of diabetic nephropathy depending on type 1 diabetes mellitus duration
Journal Title: Міжнародний ендокринологічний журнал - Year 2017, Vol 13, Issue 2
Abstract
The objective — to establish the incidence of diabetic nephropathy (DN) depending on duration of type 1 diabetes mellitus (DM), and also the content of cystatin С as a marker of early kidney damage. Materials and methods. Twenty eight patients with type 1 DM were enrolled in prospective study (11 men and 17 women aged 34.8 ± 7.2 years). Clinical and functional examination included the standard evaluation of renal function, and also the study of serum level of cystatin С. Results. In 17 out of 28 patients, the indexes of glomerular filtration rate calculated using the formulas of CKD-ЕРIcreat and CKD-ЕРIcys, indicated the different stages of chronic kidneys disease. Conclusions. Determination of cystatin C level and calculation of glomerular filtration rate using this index allows diagnosing the preclinical stages of kidney dysfunction in patients with type 1 DM in the normal creatinine level in the blood and without decline in glomerular filtration rate calculated using creatinine value. According to a retrospective study, the incidence and severity of DN in patients with type 1 DM increases with disease duration of more than 10 years.
Authors and Affiliations
V. A. Maslianko
Keywords
Related Articles
- EP ID EP176308
- DOI 10.22141/2224-0721.13.2.2017.100607
- Views 33
- Downloads 0
Possibilities of Continuous Glucose Monitoring System Use in Diabetes Mellitus Type 1
No abstract
Selenium and Thyroid Disorders
Information about the importance of selenium for thyroid homeostasis, the role of selenium deficiency in the pathogenesis of thyroid disorders, as well as the effectiveness of using selenium-containing drugs in the treat...
Economic Efficiency of Neonatal Screening for Congenital Adrenal Hyperplasia in Ukraine
In 2012, neonatal screening (NS) for congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency has been introduced in Ukraine. For a year, as part of the screening we have examined 493,580 newborns. In total,...
Clinical Manifestation, Course and Results of the Treatment of Patients with Osteoarthritis and Hypothyroidism: Age and Gender Aspects
The objective is to investigate the prevalence of subclinical and clinical hypothyroidism in a cohort of patients with osteoarthrosis (OA) and its impact on clinical features, course and results of treatment of OA. Mater...
Rare case of chiasm glioma in woman with hypogonadotropic hypogonadism and obesity
Chiasm glioma is a rare disease characterized by a decrease in the visual field. The aim of research was to describe a clinical case of chiasm glioma with concomitant hypogonadism and obesity. Reproductive function in 25...