Early Drug Discovery Prediction of Proarrhythmia Potential and Its Covariates
Journal Title: The AAPS Journal - Year 2015, Vol 17, Issue 4
Abstract
Authors and Affiliations
Sebastian Polak, Michael K. Pugsley, Norman Stockbridge, Christine Garnett, Barbara Wiśniowska
DARPP-32 mediates the actions of multiple drugs of abuse
Drugs of abuse share the ability to enhance dopaminergic neurotransmission in the dorsal and ventral striatum. The action of dopamine is modulated by additional neurotransmitters, including glutamate, serotonin and adeno...
What about Pain in Disorders of Consciousness?
The management and treatment of acute pain is very difficult in non-communicative patients with disorders of consciousness (i.e., vegetative state/unresponsive wakefulness syndrome (VS/UWS) and minimally conscious state)...
Pharmacometric Models for Characterizing the Pharmacokinetics of Orally Inhaled Drugs
During the last decades, the importance of modeling and simulation in clinical drug development, with the goal to qualitatively and quantitatively assess and understand mechanisms of pharmacokinetic processes, has strong...
MicroPET investigation of chronic long-term neurotoxicity from heavy ion irradiation
Positron emission tomography (PET) permits imaging of the regional biodistribution and pharmacokinetics of compounds labeled with short-lived positron-emitting isotopes. It has enabled evaluation of neurochemical systems...
Drug compounding for veterinary patients
Drugs have been compounded for veterinary practice for many years because it has been necessary in the course of routine practice. However, regulations and compliance policy guidelines (CPGs) should be recognized. A new...