Early Stage Oral Submucous Fibrosis is Characterized by Increased Vascularity as Opposed to Advanced Stages
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 5
Abstract
Introduction: The degree of vascularity of the diseased mucosa in Oral Submucous Fibrosis (OSMF) has always been a matter of debate with conflicting results. Knowledge of this aspect is important to understand pathogenesis of OSMF, which in future could be translated into therapeutic strategies. Aim: In the present study, attempt has been made to investigate parameters like Mean Vascular Density (MVD), Total Vascular Area (TVA) and Mean Vascular Area (MVA) using CD34 antibody. Materials and Methods: Forty five previously untreated histopathologically diagnosed cases of OSMF were retrieved from archives and fifteen age and sex matched healthy volunteers without habits were included in the control group. Sections were immunohistochemically stained for CD 34 and morphometric analysis was performed. For statistical analysis ANOVA, Kruskal Wallis test and Mann Whitney U tests were used and p-values <0.05 were considered statistically significant. Results: MVD was more in Stage I OSMF followed by Control, Stage II and Stage III with statistically significant differences (p< 0.001). Statistically significant differences were observed in the MVD between control versus Stage III OSMF. Similarly, TVA was statistically significant when compared between control versus OSMF, control versus Stage II OSMF, control versus Stage III OSMF, Stage I versus Stage II OSMF, Stage I versus Stage III OSMF, and Stage II versus Stage III OSMF. For MVA, significant differences were between control versus OSMF, control versus Stage II OSMF, control versus Stage III OSMF, Stage I versus Stage III OSMF and Stage II versus Stage III OSMF. Conclusion: Angiogenesis is seen in early stages of OSMF with decreasing trend in advanced stages. Decreased vascular areas seen in advanced stages could be attributed to the increasing fibrosis surrounding the blood vessels.
Authors and Affiliations
Satyajit Ashok Tekade, Minal S. Chaudhary, Suruchi Satyajit Tekade, Sachin C. Sarode, Sangeeta Panjab Wanjari, Amol Ramchandra Gadbail, Panjab V. Wanjari, Madhuri Nitin Gawande, Sheetal Korde-Choudhari, Prajakta Zade
Keywords
Related Articles
- EP ID EP347182
- DOI 10.7860/JCDR/2017/25800.9948
- Views 60
- Downloads 0
Correspondence: Overweight/Obesity: An Emerging Epidemic in India
Letter to Editor
Histomorphological Study of the Endometrium in Response to Insulin Resistance Induced by High Energy Diets in Swiss Albino Mice
ABSTRACT Introduction: The morphology of endometrium is continuously influenced by hormones in each menstrual cycle. In addition to this, metabolic syndrome such as obesity and insulin resistance affects the morphology o...
Paroxysmal Atrial Fibrillation due to Venomous Snake Bite
Snake bites are common all around the world with a great prevalence in South Asia and the Indian subcontinent. Although they are associated with common complications such as local swelling, bleeding at site of bite, coag...
Application of Curved MPR Algorithm to High Resolution 3 Dimensional T2 Weighted CISS Images for Virtual Uncoiling of Membranous Cochlea as an Aid for Cochlear Morphometry
Introduction: With the use of various surgical techniques, types of implants, the preoperative assessment of cochlear dimensions is becoming increasingly relevant prior to cochlear implantation. High resolution CISS prot...
Cross Cultural Adaptation, into Gujarati, of the English version, Strengths and Difficulties Questionnaire
Introduction: Adolescent mental health is a neglected entity today which needs to be addressed at the earliest. Several mental health screening questionnaires and tools are available for the same. Aim: To translate and v...