Ebola virus disease - A comprehensive review
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2014, Vol 3, Issue 4
Abstract
Ebola virus disease (EVD) is caused by infection with Ebola virus. Ebola virus disease first appeared in 1976 in 2 simultaneous outbreaks, one in Nzara, Sudan, and the other in Yambuku, Democratic Republic of Congo. The latter occurred in a village near the Ebola River, from which the disease takes its name. Fruit bats are considered possible natural hosts for Ebola virus. Ebola virus enters the patient through mucous membranes, breaks in the skin, or parenterally. EVD is often characterized by the sudden onset of fever, intense weakness, muscle pain, headache and sore throat. No FDA-approved vaccine or medicine is available for Ebola. Several vaccines are being developed and the two most advanced vaccines identified based on recombinant vesicular stomatitis virus expressing an Ebola virus protein (VSV-EBOV) and recombinant chimpanzee adenovirus expressing an Ebola virus protein (ChAd-EBOV) – are currently being tested in humans for safety and efficacy and trials were started. Scientists are working on variety of vaccines and antiviral drugs for Ebola viruses. Increasing public awareness and prevention of Ebola virus disease (EVD) spreading are the presently needed essentials for the community.
Authors and Affiliations
Babin D Reejo
Keywords
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