Effect of verapamil and nimodipine in reversing the ethanol withdrawal induced anxiety in rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2015, Vol 4, Issue 3
Abstract
BACKGROUND AND OBJECTIVE Anxiety that occurs during alcohol withdrawal may be the precipitating factor for relapse of alcoholism. Earlier studies have demonstrated calcium channel activity peaks during alcohol withdrawal and calcium channel antagonists were found to decrease behavioral manifestations of alcohol withdrawal syndrome. The objective of the study was to evaluate the anxiolytic potential of calcium channel antagonists, verapamil and nimodipine during ethanol withdrawal in rats. METHODOLOGY Male wistar albino rats were fed with 10% ethanol liquid diet for 4 weeks. Ethanol was withdrawn 8 hours before test procedure. Verapamil (20mg/kg) and nimodipine (10mg/kg) were administered orally. Elevated plus maze (EPM) and Open field test (OFT) were used to assess the anxiolytic activity. RESULT In the EPM model, the time spent in the open arm and closed arm was increased and decreased respectively in rats treated with both verapamil and nimodipine as compared to control. Number of rearing in open arm and closed arm were also increased which shows increased exploratory behavior in rats. In OFT model, the time spent in central squares and peripheral squares was increased and decreased respectively in rats treated with verapamil and nimodipine as compared to control. Number of entries into the central area and the number of lines crossed in central and peripheral areas were also increased in drug treated rats as compared to control. Number of rearing was significantly increased in the central areas but not in the peripheral areas. CONCLUSION Verapamil and Nimodipine significantly reduced ethanol withdrawal induced anxiety. Calcium channel antagonists could be effectively used as alternative to benzodiazepines in ethanol withdrawal induced anxiety.
Authors and Affiliations
R. Saravanan R. Saravanan
Keywords
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