Echocardiographic Changes in Overt and Subclinical Primary Hypothyroidism
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 6, Issue 1
Abstract
Background and Objectives: Thyroid hormone is an important regulator of cardiac function and cardiovascular hemodynamics. The aim of this study was to assess the cardiovascular functions in primary overt and subclinical hypothyroid patients and to determine if there was a correlation between severity of disease and echocardiographic changes. Methodology: A cross-sectional study was conducted in the Endocrinology Clinic of Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai. The study sample was grouped into mild, moderate, severe, and subclinical hypothyroid groups which were then compared by echocardiographic findings. Results: A total of 84 patients were seen, from June 2013 to September 2013. Abnormal left ventricle posterior wall (LVPW) thickness and abnormal interventricular septal wall (IVSW) thickness were more frequently noted in those with clinical hypothyroidism (moderate and severe) as compared to those with subclinical hypothyroidism. Abnormal septal wall thickness was noted in 9 (69.23%) of moderately hypothyroid and 18 (72%) of severely hypothyroid patients, whereas this finding was noted in only 5 (16.66%) of the subclinical hypothyroid patients indicating significant differences between the groups. Diastolic dysfunction was also significantly more frequent in the moderate and severe hypothyroid group. On statistical analysis by one-way analysis of variance, it was found that LVPW (mm), IVSW (mm), and E/A ratio were significantly associated with the severity of hypothyroidism, while ejection fraction, fractional shortening, and LV internal diameter were not significantly different between groups. Conclusions: The completely reversible nature of these cardiac complications being well known, this study aims at reassessing the need for early recognition, and more aggressive management aims at preventing the aforementioned complications.
Authors and Affiliations
Haridoss Sripriya Vasudevan, J Jacinth Preethi
Keywords
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