Echocardiographic evaluation of left ventricular parameters in patients with Cushing’s syndrome
Journal Title: Postępy Nauk Medycznych - Year 2013, Vol 26, Issue 11
Abstract
Introduction. Cushing’s syndrome is characterized by the wide spectrum of metabolic abnormalities and systemic complications. Patients with Cushing’s syndrome, regardless of the cause of hipercortisolism, have enhanced cardiovascular risk and increased mortality rate. An association between hipercortisolism and a variety of cardiac functional and structural changes seen in echocardiography was previously reported.Aim. To retrospectively assess the metabolic status and echocardiographic alterations of left ventricle (LV) in patients with Cushing’s syndrome.Material and methods. The studied group consisted of 10 subjects (8 females and 2 males) with Cushing’s syndrome, aged 22-70 yrs (mean 45.8 yrs. ± 14.2). In 8 cases hipercortisolism resulted from ACTH-dependent Cushing’s syndrome (6 cases of pituitary adenoma and 2 cases of ACTH ectopic secretion) and other 2 were caused by ACTH-independent Cushing’s syndrome due to adrenal lesion. All of the subjects were in the active phase of disease. The prevalence of overweight/obesity, hypertension, diabetes and dyslipidemia was assessed. Analysis of left ventricular parameters obtained in echocardiography was performed.Results. Our studied group was found to have high prevalence of overweight/obesity, diabetes, dyslipidemia and hypertension.Ejection fraction and left ventricular dimensions were within normal range in entire group under the study. Almost all study participants presented abnormalities in left ventricular parameters including enhanced septum diameter, increased posterior wall thickness and relative wall thickness as well as LV mass and LV mass index out of normal range.Conclusions. As the left ventricular dysfunction and structural changes are commonly found in Cushing’s syndrome, echocardiographic evaluation should be performed in all patients with cortisol overproduction.
Authors and Affiliations
Agnieszka Baranowska-Bik, Agata Popielarz-Grygalewicz, Marek Dąbrowski, Wojciech Zgliczyński
Keywords
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