EFAVIRENZ, A WELL KNOWN ANTIVIRAL DRUG, MIGHT BE A NEW OPTION IN THE TREATMENT OF CANCER
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 7
Abstract
Cancer is a potentially fatal disease, where cells abnormally divide which hurts the tissues. The incidences of cancer are increasing worldwide and become one of the leading causes of death. A numbers of anticancer agents are available in the market or under clinical trials used for its treatment, but unfortunately, none of them is able to treat cancer. Thus, the exploration of novel mechanistic pathways of existing molecules may help to develop more effective anticancer agents. Efavirenz, a well-known non-nucleoside reverse transcriptase inhibitor, used in the highly active antiretroviral therapy (HAART) for the treatment of human immunodeficiency virus (HIV) infected patients with tolerable side effects. Newly emerging data revealed that efavirenz has the potential to induce toxic effects against a wide range of cancer cells by altering various cancer pathways. Thus, this existing antiretroviral drug with already known safety profiles could be rapidly utilized for the treatment of various cancers.Keywords: Efavirenz, Endogenous reverse transcriptase, Apoptosis, Anticancer
Authors and Affiliations
Anoop Kumar
Keywords
Related Articles
- EP ID EP576200
- DOI -
- Views 38
- Downloads 0
STABILITY INDICATING HPTLC METHOD FOR DETERMINATION OF CLEVIDIPINE BUTYRATE IN SYNTHETIC MIXTURE
Objective: To develop and validate stability indicating HPTLC method for determination of clevidipine butyrate in synthetic mixture.Methods: The present study deals with development and validation of stability indicating...
IN VITRO CYTOTOXICITY EFFECT ON MCF-7 CELL LINE OF CO-ENCAPSULATED ARTESUNATE AND CURCUMIN LIPOSOME
Objective: Cancer drug delivery has focused using novel carrier system due to their high drug loading and release controlled property and minimum side effect. Artesunate (ART) and curcumin (CUR) are proved natural herbal...
DEVELOPMENT AND VALIDATION OF UV-VISIBLE SPECTROSCOPIC METHOD FOR ESTIMATION OF CARBAMAZEPINE IN BULK AND TABLET DOSAGE FORM
Objective: To develop and validate simple, accurate, rapid, precise, reproducible and cost effective spectrophotometric method for the quantitative estimation of carbamazepine in a pharmaceutical formulation.Methods: The...
SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME INDOLE ANALOGUES CONTAINING TRIAZOLE-5-THIOL AND THIAZOLOTRIAZOLE SYSTEMS
Objective: The present study aims at the synthesis and evaluation of antimicrobial and antioxidant activities of indole analogues incorporated with triazole and thiazolotriazole moieties.Methods: The newly synthesized co...
CHEMICAL COMPOSITION OF THE HEXANE EXTRACT OF LEAVES OF AZIMA TETRACANTHA (LAM)
Objective: In the present study, the phytochemical constituents of hexane extract from Azima tetracantha (AT) leaves were done by using Gas Chromatography Mass Spectrometry analysis technique (GC-MS). Azima tetracantha h...