Effect of 12 Weeks of Treadmill Aerobic Training on Cytochrome c and Caspase-9 gene Expression in Cardiac Muscle of Male Rats
Journal Title: مجله علمی- پژوهشی دانشگاه علوم پزشکی قم - Year 2017, Vol 11, Issue 6
Abstract
Background and Objectives: Apoptosis plays an important role in the development of cardiovascular diseases, especially heart failure. Some evidences suggest that exercise training may alter apoptosis-related signaling in somatic tissues such as the myocardium. The purpose of the present study was to determine the effect of 12 weeks of treadmill aerobic training on cytochrome c and caspase-9 gene expression in cardiac muscle of male rats. Methods: This study was conducted as a two-group experimental design project (animal model) on 16 3-month-old male rats. Animals were randomly divided into two homogeneous groups of aerobic training and control (8 animals each). Animals of the training group underwent an aerobic training program for 12 weeks (75-80% VO2max). Forty-eight hours after the last training session, their hearts were extracted and cytochrome c and caspase-9 genes, were evaluated by RT-PCR. Data were analyzed using independent t-test at the significance level of p<0.05. Results: Cytochrome c gene expression in the experimental group was significantly higher than the control group (140.62%, p<0.05). The expression of caspase-9 gene, was also significantly higher in the experimental group compared to the control group (333.92%, p<0.05). Conclusion: Overall, it seems that 2-weeks of aerobic training on treadmill has a significant effect on the increased the expression of key genes of the cardiac mitochondrial apoptosis pathway. However, the underlying mechanisms of these effects are unclear and require further researches.
Authors and Affiliations
Nasrin Nasrin, Jabbar Jabbar, Mohammad Mohammad
Keywords
Related Articles
- EP ID EP464697
- DOI -
- Views 33
- Downloads 0
تأثیر 10 هفته تمرین مقاومتی بر سطح سرمی میوستاتین و ترکیب بدنی در نوجوانان چاق
زمینه و هدف: مطالعات، نشان‌دهنده نقش تنظیمی منفی میوستاتین در رشد عضله اسکلتی است. در مطالعه حاضر تأثیر 10 هفته تمرین مقاومتی بر تغییرات سطح سرمی میوستاتین و ترکیب بدنی در نوجوانان چاق بررسی گردید. روش بررسی: در این مطا...
The Effect of Combined Exercise Training and Feroglobin Supplementation on Serum Iron and Lipid Profile in Women with Iron Deficiency Anemia
Background and Objectives: Iron can play an important role in exercise performance of women. The purpose of the present research was to determine the effects of combined exercise training and Feroglobin supplementation o...
Antibacterial activity of essential oil and extracts of Achillea tenuifolia against pathogenic bacteria
Background and Objectives: Chemical drugs have many side-effects, and for this reason, the approach of using medicinal plants and traditional medicine, has increased. Achillea tenuifolia is a plant belonging to the famil...
ردیابی ژن‌های اگزوتوکسین S، U، T، Y، A در سودوموناس آئروژینوزا مقاوم به سفالوسپورین‌های نسل سوم جداشده از نمونه‌های بالینی بیماران بستری در بیمارستان‌های شهر قم
زمینه و هدف: یکی از شایع‌ترین مشکلات در بیمارستان‌ها، عفونت‌های ایجاد‌شده توسط باکتری سودوموناس آئروژینوزا می‌باشد که برای انسانها یک پاتوژن فرصت‌طلب محسوب می‌شود. 5 آنزیم مهم شامل: اگزوتوکسین S، U، T، Y، A فاکتورهای مهم...
The Effect of 8 Weeks of Moderate-Intensity Endurance Training on Serum Levels of Liver Enzymes and Insulin Resistance Index in Women with Type 2 Diabetes
Background and Objectives: Type 2 diabetes is the most common type of diabetes and liver damage is one of its most important complications. In the present study, the effect of endurance training, was investigated on plas...