Effect of 5-HT4 receptors agonist (mosapride citrate) on lipidperoxidation, Nitrogen (II) oxide production and morphology of colon mucosa under the conditions of ulcerative colitis
Journal Title: Біологія тварин - Year 2016, Vol 18, Issue 2
Abstract
Serotonin plays an important role in function regulation of the gastrointestinal tract, including the colon. We know that almost all of human body’s serotonin is synthesized and deposited in enterochromaffin cells localized in colon mucosa. Implementation of serotonin influence on smooth muscles, blood vessels and colon mucosa is performed by activating various types of serotonin receptors. 5-HT4 receptors play significant role among them as they are identified on cell membranes of the colon (enterocytes, smooth muscle, endothelium). We used mosapride citrate — a 5-HT4 receptors agonist to determine their role. The study was conducted in nonlinear rats of both sexes, who were divided into 4 groups (first — intact animals, second — animals, injected 5-HT4 receptors agonist, third — animals with experimental colitis, fourth — animals injected 5-HT4 receptors agonist under condition of experimental colitis). Colitis was modeled by introducing a solution of acetic acid in the colon. The colitis was accompanied by increased activity of lipid peroxidation processes, inducible NO-synthase, myeloperoxidase, which causes the development of nitrozo-oxidative stress. Mosapride action does not lead to severe morphological and biochemical changes in the colon mucosa. Activation of 5-HT4 receptors by mosapride under the condition of colitis reduced degree of destructive damage, content of TBA-active products, the activity of myeloperoxidase, inducible NO-synthase, superoxide dismutase and catalase in the colon mucosa, indicating a decrease of nitrozo-oxidative stress and strengthening of cytoprotection. Application of mosapride citrate has not only prokinetic effect, but also cytoprotective, antioxidant and anti-inflammatory under condition of experimental colitis.
Authors and Affiliations
N. Denysenko, A. Sklyarov
Keywords
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- EP ID EP234671
- DOI 10.15407/animbiol18.02.036
- Views 96
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