Effect of Age and Diabetic Duration on Levels of Microalbuminuria among Type 2 Diabetic Patients
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 12
Abstract
Abstract: Out of 10, one adult will encompass diabetes by 2030; facts indicate that the figure of persons inhabiting with this disorder is anticipated to go up from 366 million in 2011 to 552 million by 2030, if no critical act is undertaken. During the first 5 years of diabetes, thickening of the glomerular basement membrane, glomerular hypertrophy, and mesangial volume expansion occur as the GFR returns to normal. After 5–10 years of type 1diabetes, nearly 40% of individuals begin to excrete small amounts of albumin in the urine.1 Microalbuminuria is present in 20-30% of all patients with type 2 diabetes mellitus, and is especially common in those with hypertension, endothelial dysfunction and other features of insulin resistance. Thus, the present study was conduct to estimate microalbuminuria among type 2 diabetes mellitus and to correlate age and diabetic duration with the levels of microalbuminuria among such patients. The case-control study was conducted in the Department of Biochemistry, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana (Ambala), India by taking fifty diagnosed cases of type 2 diabetes mellitus and fifty age and sex matched apparently healthy controls. It was found that the prevalence of microalbuminuria was 52 %. In type 2 diabetic patients, mean FPG and microalbuminuria were higher as compared with healthy controls. Thus, there was significant difference (p<0.001) in levels of FPG and microalbuminuria. Further, there was strong correlation between microalbuminuria and glycemic control. Also, there was significant correlation of microalbuminuria with age and the duration of diabetes in type 2 diabetic patients. With the increase in duration of diabetes, there was significant progression of microalbuminuria to macroalbuminuria (>300 mg/day). Hence, it was concluded that the early determination of microalbuminuria should be implemented in clinical practice for overall risk evaluation, at least in diabetic patients.
Authors and Affiliations
Dr. Jai Prakash Bhartiya, Narendra Kumar Sah, Dr. Harpreet Kaur Walia, Dr. Kamaljit Singh
Keywords
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