Effect of analgesics from different groups on renal functions of healthy male albino rats
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2016, Vol 20, Issue 3
Abstract
Objective: 1.To determine the extent of affection of renal functions of analgesics from different groups and to compare the drugs with relation to the renal parameters. 2. To determine the least nephrotoxic drugs among the groups based on affection of renal parameters. Material and Methods: With prior approval from animal ethical committee four groups of Adult Male albino rats weighing 160-200 g with 6 in each group were selected. The normal urinary output for 24 hrs and urinary protein excretion for 24 hrs, urine creatinine, androutine urine examination are observed for each animal keeping it in a metabolic cage for 24 hrs. Blood was drawn from the lateral tail vein of rat and Blood urea, serum creatinine are estimated. Then the same animal was administered with the test drugs indomethacin(8 mg/kg) etorcoxib (9 mg/kg) Paracetamol (25 mg/kg,)Ibuprofen(15 mg/kg)respectively for 3 days with appropriate dose and 24 hrs of urine output is observed and all the above test are repeated for each drug on the 4thday.The observations were tabulated and results are statistically analysed. Results: The results showed significant changes inp H (*P=0.001), Urea (*P=0.05),creatinine(*P=0.02) levels in case of Paracetamo l,etorcoxib showed prominent changes in urinary creatinine level (**P=0.035). P vaues showed Positive significance with regards to paracetamol and etorcoxib. With regards to drug ibuprofen and indomethacin significant changes were in serum creatinine and urine creatinine levels(*P=0.05.)P values showed Negative significance in case of indomethacin and ibuprofen. Conclusion: Blood urea and serum creatinine are important parameters with regards to assesment of renal functions. The drugs paracetamol, etorcoxib, administered to albino rats for a short duration of 3 days clearly demonstrated a decline in the renal function parameters. Paradoxically drugs Indomethacin and ibuprofen have demonstrated a benefitial effect on the parameters of renal functions.
Authors and Affiliations
Brahadeesh M, Mohan J, Thamilarasi s, P K Mohanty, Denesh Kumar V
Keywords
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