EFFECT OF AQUEOUS EXTRACT OF PUNICA GRANATUM FLOWER ON BIOMARKERS AND ECG CHANGES IN ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION IN RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
The present study was designed to investigate the effect of aqueous extract of Punica granatum flower (PG) against isoproterenol (ISO) induced myocardial infarction (MI) in rats by studying cardiac markers and electrocardiographic changes. MI was induced in rats by subcutaneous injection of ISO (150mg/kg b.w) at an interval of 24 hours for 2 days. ISO treated rats showed significant increase in cardiac markers such as Lactate dehydrogenase (LDH), Creatine kinase (CK-MB), Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) in serum. Altered ECG pattern with ST segment elevation, which conforms the MI. Oral pretreatment with PG at 400mg/kg and Vitamin E (100mg/kg as a standard) daily for a period of 28 days showed significant decrease in serum cardiac marker enzymes level and ECG alterations. Thus the result suggests that PG has cardioprotective effect in ISO induced myocardial infracted rats.
Authors and Affiliations
N. A. Khatib , Jignesh Patel , Swathi Medi
Keywords
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