Effect of atorvastatin, with or without ezetimibe, on serum lipid profile and ALT in hyperlipidemic patients
Journal Title: ZANCO JOURNAL OF MEDICAL SCIENCES - Year 2011, Vol 15, Issue 1
Abstract
Abstract Background and objectives: Hyperlipidaemia is raised serum levels of one or more of total cholesterol, low-density lipoprotein and triglycerides. Many drugs have been used for the treatment of this disorder. This work compares the effects of atorvastatin with or without ezetimibe on lipid profile, atherogenic index and serum alanine aminotransferase. Methods: This study covers 90 subjects, 60 untreated hyperlipidemic patients, and 30 healthy subjects. Patients were divided into 2 groups, the first group included 30 patients treated with atorvastatin 20 mg/day alone, the second group included 30 patients treated with a combination of 2 drugs (atorvastatin 10 mg plus ezetimibe 10 mg) taken daily at night. Serum lipid profile, atherogenic index and serum alanine amniotransferase were measured after 12 hours fasting for the patients in 3 intervals: before, and after 8 weeks and 16 weeks of treatment. Results: After therapy for both groups of patients, as compared to the levels before treatment, has shown that serum total cholesterol, triglycerides, low density lipoprotein cholesterol and very low density lipoprotein cholesterol were significantly reduced while high density lipoprotein cholesterol was significantly increased. Serum alanine aminotransferase increased by both groups of treatment with no significant difference between the two modes of treatment which has the same findings in comparison to the control group. Conclusion: Combination of atorvastatin 10 mg and ezetimibe 10 mg daily, is more effective than atorvastatin 20 mg taken alone. Key words: hyperlipidaemia ,atherogenic index , atorvastatin ,ezetimibe, alanine aminotransferase,
Authors and Affiliations
Showan D. Husain , Wishyar Abbas Hamad
Keywords
Related Articles
- EP ID EP129512
- DOI -
- Views 188
- Downloads 0
Antihyperuricemic and diuretic effects of procyanidins extracted from Crataegus monogyna
Background and objectives: Data indicated that procyanidins extracted from grape seeds has uric acid-lowering effects in mice, however the hypouricaemic effect of procyanidins was accompanied with changes in enzymatic ac...
Serum sialic acid and its lipid and protein bounds as possible biomarkers of acute myocardial infarction in Erbil city
Backgrounds and objectives: Myocardial infarction (MI) usually occurs when coronary blood flow decreases abruptly after a thrombotic occlusion of a coronary artery previously affected by atherosclerosis. Sialic acid (SA)...
Clinical study of cases with hyperthyroidism in Erbil Governorate, Kurdistan Region-Iraq
Abstract Background and objectives: Thyrotoxicosis is a common and serious world-wide health problem, it’s one of the common problems in Erbil governorate. Methods: Clinical analysis done for 675 patients proved to...
Association of certain sociodemographic and clinical characteristics of diabetic patients with quality of life
Background and objectives: Diabetes mellitus is a common and demanding health problem that has a great effect on everyday life of patients. This study was done to determine sociodemographic and clinical characteristics t...
Infestation rate with polyplax spinulosa (burmeister, 1839) among certain laboratory albino rats (rattus norvegicus) in relation to different washing agents in two Erbil city universities
Backgrounds and objectives: The ectoparasite Polyplax spinulosa (Class: Isecta; Sub-Order: Anoplura; Familiy: Polyplacidae) was found to act as a biological vector of some pathogenic virus, bacteria and protozoa. The mai...