Effect of Azithromycin and Rosuvastatin on animal models for skeletal muscle relaxant activity in Swiss albino mice
Journal Title: World Journal of Pharmaceutical Sciences - Year 2016, Vol 4, Issue 12
Abstract
The objective of the study was to evaluate the effect of Azithromycin and Rosuvastatin on animal models for skeletal muscle relaxant activity in Swiss Albino Mice by using Rotarod and actophotometer. Statins affect skeletal muscle contraction and it is metabolized by CYP3A4. Macrolide antibiotics inhibit CYP3A4 and it can be co-administered along with statins. For this study 30 healthy albino mice were randomly selected and divided into 5 equal groups. Rota rod test and Locomotor activity by Actophotometer was observed for 5mins before and after intragastric administration of distilled water 0.5ml, Diazepam (4 mg/kg), Azithromycin 100mg/kg, Rosuvastatin 2mg/kg and combination of Azithromycin (100mg/kg) + Rosuvastatin (2mg/kg) to mice of group 1 to 5 respectively. The results were analyzed statistically. Rosuvastatin and Azithromycin produced no significant effect on motor coordination and locomotor activity in albino mice.
Authors and Affiliations
Dr. Rajesh M
Keywords
Related Articles
- EP ID EP205130
- DOI -
- Views 79
- Downloads 0
Preparation and Characterization of a Novel Preparation of Itraconazole Nanoparticles with Improved Dissolution and Bioavailability
The aim of the present work is to utilize the nanotechnology for preparing stable nanoparticles that enhance the dissolution and hence the bioavailability of poorly water-soluble Itraconazole (ITZ). ITZ nanosuspensions w...
Polymorphic evaluation of Rabeprazole sodium
Regulatory authorities throughout the world require all possible crystalline forms of the same active drug compound be synthesized and characterized as completely as possible. Rabeprazole sodium, a proton pump inhibitor,...
Allergic foods to be avoided in eczematic patients -A Siddha perspective
Food allergy is an immune system reaction that occurs soon after eating a certain food. Even a small amount of allergy causing food can trigger signs and symptoms such as digestive problem, skin problems, respiratory dis...
Effect of Supplementation of Herbal Antistress Product and Synthetic Vitamin C on performance of broiler birds under physiological heat Stress
An experiment was carried out on 135 day old Vencob straight run commercial broiler chicks for a period of 42 days (6 weeks). The chicks were randomly divided into three groups (n=45) of three replicates each. Untreated...
Effect of Panax ginseng on glucose level and lipid profile of normal and diabetic male rats (Rattus norvegicus)
The present study was designed to investigate the effects of the Panax ginseng on glucose level and lipid profile of normal and diabetic male rats. Thirty six mature male rats were used, these animals were divided into s...