EFFECT OF BACOSIDE A ON LIPID PEROXIDATION IN D-GALACTOSE INDUCED AGING MICE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2017, Vol 9, Issue 9
Abstract
Objective: Bacoside A is a major bioactive constituent of Bacopa monnieri L having antioxidant property. The objective of this study was to evaluate the effect of Bacoside A, on lipid peroxidation in brain, heart and liver during induced aging.Methods: Male Swiss albino mice, Mus musculus was used for the present investigation. Four experimental groups were used as Group I-Normal adult, Group II-D-galactose induced, Group III-D-galactose induced plus Bacoside A treated and Group IV-Natural aging. The effect of Bacoside A was studied against lipid peroxidation during induced aging. The level of lipid peroxidation in the form of MDA formation was determined and measured in brain, heart and liver.Results: The statistical data obtained were analyzed using one way ANOVA, control vs other groups and results were expressed as mean±SE. In Bacoside A treated group the lipid peroxidation level in heart, brain and liver was significantly decreased (p<0.001) compared to control group. A significant increase (p<0.0001) in the level of lipid peroxidation was observed in D-galactose induced mice. In natural aging group highly significant increase (p<0.0001) in initial lipid peroxidation, ascorbate dependent lipid peroxidation and spontaneous lipid peroxidation was observed.Conclusion: The observations revealed that, lipid peroxidation was reversed in Bacoside A treated group which may be due to antioxidant property of Bacoside A. Thus Bacoside A is able to ameliorate the stress induced changes in lipid peroxidation during aging. The findings also provide a theoretical basis for the development of novel therapeutic formulations, such as antioxidant supplementation to boost antioxidant defenses in the body.
Authors and Affiliations
Sushama Pawar, Manmohini Jadhav
Keywords
Related Articles
- EP ID EP575486
- DOI 10.22159/ijpps.2017v9i9.16874
- Views 83
- Downloads 0
UROLITHIASIS–AN UPDATED REVIEW OVER GENETICS, PATHOPHYSIOLOGY AND ITS CLINICAL MANAGEMENT
Urolithiasis is the formation of renal calculi within the urinary tract of susceptible individual of various etiopathogenic factors with a complex pathogenic manifestation. It is a worldwide problem which was evident fro...
ESSENTIAL OILS AND METHYLGLYOXAL: A POSSIBLE ALTERNATIVE TREATMENT FOR ANTIBIOTIC RESISTANT BACTERIAL INFECTIONS
Objective: Essential oils are of significant interest in today’s world of healthcare because these compounds have a variety of medicinal properties. In this study, we evaluated the in vitro antibiotic role of essential...
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD OF NEPAFENAC AND ITS DEGRADATION PRODUCTS: APPLICATION TO DEGRADATION KINETIC
Objective: The objective of present work was to develop and validate simple, precise, accurate and specific stability indicating method for determination of nepafenac in presence of its degradation products and applicati...
SYNTHESIS, FREE RADICAL SCAVENGING AND DNA CLEAVAGE ACTIVITIES OF SOME NOVEL INDOLE DERIVATIVES
Objective: Synthesis of a series of novel indole derivatives (6a-h) by condensation of indolyl chalcones (5a-h) with thiobarbituric acid to evaluate free radical scavenging and DNA cleavage activity.Methods: The newly sy...
TO STUDY THE ROLE OF EXERCISE AND DIETARY MANIPULATION IN OBESE RATS TREATED WITH ORLISTAT
Objective: The present study was undertaken to evaluate the role of exercise and dietary manipulation in obese rats treated with Orlistat.Methods: The study was conducted for 16 weeks. High-fat diet (HFD) was used to ind...