Effect of Bioenteric Intragastric Balloon (BIB) insertion on hormones regulating lipid metabolism, a prospective study.
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2015, Vol 1, Issue 1
Abstract
BACKGROUND: The prevalence of obesity is increasing worldwide. Obesity is associated with a number of healthrelated problems, so treating obesity is an important clinical concern. Bioenteric Intragastric Balloon (BIB) can be an option for treating obesity. Body weight is regulated by a complex system including both peripheral and central factors. Many hormones including Leptin and Ghrelin seem to play an important role in the regulation of food intake and body weight. Few reports are available on the effect of Bioenteric Intragastric Balloon (BIB) on hormonal regulation in patients with obesity. OBJECTIVES: The aim of this study was to investigate the effect of Bioenteric Intragastric Balloon (BIB) insertion on hormones regulating lipid metabolism. METHODS: The study was conducted on 20 patients with BMI > 30 Kg/m² presented for Bioenteric Intragastric Balloon (BIB) insertion during the period between January 2013 and January 2014. Balloon was removed after 6 months with no complications. Complete lipid profile, serum level of Leptin and Ghrelin were measured before and after removal of the balloon. RESULTS: The use of Bioenteric intragastric balloon (BIB) for 6 months caused a significant reduction in body weight and BMI. The mean weight of the participants decreased to 98.75 Kg and mean BMI decreased to 32.45 Kg/ m 2 . The mean weight loss was 14.70 Kg. The mean loss in BMI was 5.01 Kg/m2. The excess weight loss (EWL) was 12.95 % and the excess BMI loss (EBL) was 13.34 %. There was a significant reduction in Fasting blood sugar, HbA1c, serum creatinine, serum cholesterol, serum triglycerides, serum LDL and serum Leptin level Meanwhile use of BIB caused a significant increase in serum Ghrelin level.CONCLUSIONS: Insertion of Bioenteric intragastric balloon (BIB) for 6 months significantly reduces body weight and BMI. Moreover, Intragastric balloon strongly affects glucose homeostasis, lipid metabolism in addition to hormones involved in energy balance mainly serum leptin and ghrelin
Authors and Affiliations
Hany Haroun Kaisara , MD; Youhanna shohdy shafikb ,
Keywords
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