Effect of Breath’In On Oxidative Pulmonary Damage and Fibrosis in A Rodent Model
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 3
Abstract
Aim: The present study evaluated the protective effects of Breath’In, on oxidative damage and fibrosis in the lungs of rats. Method: Pulmonary damage and fibrosis was induced in female Sprague Dawley rats using CCl4 (3 ml/kg b.w. i.p., 20% v/v CCl4/olive oil) for 28 days. The role of Breath’In in reversing the effects of CCl4 was studied by measuring the levels of superoxide dismutase, catalase, glutathione and collagen in lung tissues. Results: The results showed that CCl4 exerted its toxic effects on lung tissue by decreasing the levels of SOD, CAT and GSH. In contrast, co-administration of Breath’In reversed the CCl4 induced decreases in SOD, CAT and GSH levels. While CCl4 led to a significant increase in collagen deposition, treatment with Breath’In led to a significant decrease in collagen deposition. These results were in agreement with results obtained when rats were co-treated with prednisolone. Thus, the results of this study indicate that Breath’In has the ability to reduce oxidative damage and fibrosis in lung tissues. Conclusion: Our findings suggest that Breath’In demonstrates protective properties and is effective in reducing pulmonary damage that was induced by oxidative stress produced by CCl4.
Authors and Affiliations
Kallolika Mondal1 ,, Kishor J1 . , Vidya ON1, Shivalinge Gowda KP, Shanaz Tejani- But, Nataraj Loganayaki3, Khader Shareef KS, Venkateswarlu K
Keywords
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