Formulation and Evaluation of Taste Masked Fast Disintegrating Tablet of Promethazine Hydrochloride
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2013, Vol 3, Issue 11
Abstract
Methods: Taste masking of Promethazine Hydrochloride was achieved by microencapsulation using amino alkyl methacrylate copolymers (Eudragit E100) employing the solvent evaporation technique. Taste assessment was carried out by time intensity metod. Sublimation method was used, using camphor as subliming agent, sodium starch glycolate and crosspovidone as a super-disintegrant was used to prepare fast disintegrating tablets. Tablets were evaluated with regard to a variety of pharmacopoeial tests, drug release, and disintegration time in the oral cavity.
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