Risk factors and Pathogenesis in the Development of Prosthetic ValveEndocarditis
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 8
Abstract
Mortality and morbidity in prosthetic valve endocarditis (PVE) is high despite improvements in diagnosis, therapeutic and design. Incidence of PVE is high in the initial 6 to 12 months after valve replacement and at low rate thereafter. Health care- associated infections are on the increase due to methicillin resistant Staphylococcus aureus,(MRSA),and coagulase negative staphylococci (C0NS).Community acquired PVE is caused by enterococci, Streptococcus viridans group, and fastidious organisms, including the HACEK group. Microorganisms with surface components that react with adhesive matrix molecules (MSCRAMMs),mediate colonization and infection. Frequent risk factor for infection includes intravascular devices and hemodialysis. Antimicrobial therapy of PVE do not differ from native valve endocarditis (NVE), except larger vegetations than in NVE, must be considered.
Authors and Affiliations
Murtaza Mustafa. M. Phanindranath, Rajesh K Muniandy, M. Yusof Ibrahim, Raihana Musawwir
Keywords
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