Hepatoprotective effects of simvastatin on paracetamol -induced hepatic damage in rats

Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 6


 ABSTRACT: This study was designed to investigate the possibility of statins hepatoprotection in paracetamol toxicicity. Paracetamol hepatotoxicity was associated with significant decrease in the serum total albumin(g/dl) p< 0.05) and total protein(g/dl) ( p< 0.05) . However, it significantly increased ( p< 0.0001), ALT IU/L, AST IU/L, and ALP IU/L as shown in group 3 ( positive control) in comparison with the negative control (group 1) ( table 1). Using of simvastatin 10mg/kg in healthy animals ( group 2) caused slight insignificant changes in serum total albumin(g/dl), total protein(g/dl), ALT IU/L, AST IU/L, and ALP IU/L. However, simultaneous administration of simvastatin 10mg/kg with paracetamol, significantely attenuate the adverse changes in the serum total albumin(g/dl), total protein (g/dl), ALT IU/L, AST IU/L, and ALP IU/L. However, it didn’t bring them to the normal limits.

Authors and Affiliations

Mahdi M. Thwaini , Hanaa S. Kadhem


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  • EP ID EP158610
  • DOI -
  • Views 35
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How To Cite

Mahdi M. Thwaini, Hanaa S. Kadhem (2015).  Hepatoprotective effects of simvastatin on paracetamol -induced hepatic damage in rats. IOSR Journal of Pharmacy (IOSRPHR), 5(6), 25-29. https://europub.co.uk/articles/-A-158610