Effect of Cerebroprote in Hydrolysate Inmanagement of Mild And Moderate Traumatic Brain Injury-An Institutional Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 9
Abstract
Introduction: Traumatic brain injury occurs when external force injures the brain which may include falls, violence and vehicle collisions leading to more diffuse injury causing cognitive and neuro psychiatric disturbances. Cerebroprotein hydrolysate is a peptide preparation with similar action as neurotrophic factors thus improving neurogenesis in cases of traumatic brain injury. Objectives: We attempt to determine the beneficiary effects of cerebroprotein hydrolysate and its clinical outcome in management of traumatic brain injuries in our institution. Material and Methods: This is a prospective study comprising of 300 patients admitted in Department of Neurosurgery, Government Medical College and Hospital, Guntur, Andhra Pradesh for a period of 2 years (March 2015- march 2017). Results: 300 patients were included in this study in a period of 2 years where in 210 were Male and 90 were Female.Patients were randomly divided into 2 groups. Group A and Group B with 150 patients in each group. Group A were treated with cerebroprotein hydrolysate after head injury. Group B patients did not receive the drug instead they were treated routinely. GCS in Group A patients at the time of admission for 70 patients was mild Traumatic brain injury and 80patients with moderate TBI. Where as in Group B 80 patients had mild traumatic brain injury and 70 had moderate traumatic brain injury. On assessing patients 3week post cerebroprotein infusion, amongst Group A, 110 were with mild and 40 were with moderate category of traumatic brain injury. Whereas 90 were with mild and 60 were with moderate category of traumatic injury in Group B. Conclusion: Cerebroprotein hydrolysate infusion has a beneficial effect in managing cases of acute traumatic brain injury and is safe and well tolerated by the patients
Authors and Affiliations
Dr. DuttaluruSeshadri Shekar, Dr. Rohit Reddy Arumalla, Dr. Vimala Ambati, Dr. KesanakurthiSatyanarayana Murthy
Keywords
Related Articles
- EP ID EP255716
- DOI 10.9790/0853-1609021214
- Views 82
- Downloads 0
A prospective study of two-stage primary repair for proximal hypospadias and its short term outcomes.
Aims: To study two stage repair in primary cases of proximal hypospadias using inner preputial graft and analyze short term outcomes. Methods: Single institutional prospective study of patients who underwent primary repa...
Role of Tragal Cartilage And Perichondrium in Middle Ear Reconstruction
Objective: The objective of study was to assess the efficacy of tragal perichondrium and cartilage, the functional capacity in restoring hearing acuity, it's mechanical survival, it's extrusion rate and it's functional i...
Incidence of Surgical Site Infections in Abdominal Wound Closure with Triclosan Coated Sutures
The aim of the present study is to comprehensively study and evaluate the difference in the incidence of superficial surgical site infections developing in laparotomy wounds approximated with bioactive suture material (c...
Comparison of Efficacy of Three Ni-Ti Instruments in Removal of Gutta-Percha from Root Canal during Retreatment- An In Vitro Study
Aim:This study compares the efficacy of three different retreatment file systems and determines which retreatment file requires less time in removal of previous root filling material. Methodology- Thirty anterior teeth w...
Study of red cell alloimmunisation in multigravida in RIMS hospital,Imphal
Red cell alloimmunisation is the development of antibodies in response to foreign red cell antigens through transfusion or pregnancy. Females can be alloimmunised to red cell antigens by previous transfusions or transpla...