Effect of Cerebroprote in Hydrolysate Inmanagement of Mild And Moderate Traumatic Brain Injury-An Institutional Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 9
Abstract
Introduction: Traumatic brain injury occurs when external force injures the brain which may include falls, violence and vehicle collisions leading to more diffuse injury causing cognitive and neuro psychiatric disturbances. Cerebroprotein hydrolysate is a peptide preparation with similar action as neurotrophic factors thus improving neurogenesis in cases of traumatic brain injury. Objectives: We attempt to determine the beneficiary effects of cerebroprotein hydrolysate and its clinical outcome in management of traumatic brain injuries in our institution. Material and Methods: This is a prospective study comprising of 300 patients admitted in Department of Neurosurgery, Government Medical College and Hospital, Guntur, Andhra Pradesh for a period of 2 years (March 2015- march 2017). Results: 300 patients were included in this study in a period of 2 years where in 210 were Male and 90 were Female.Patients were randomly divided into 2 groups. Group A and Group B with 150 patients in each group. Group A were treated with cerebroprotein hydrolysate after head injury. Group B patients did not receive the drug instead they were treated routinely. GCS in Group A patients at the time of admission for 70 patients was mild Traumatic brain injury and 80patients with moderate TBI. Where as in Group B 80 patients had mild traumatic brain injury and 70 had moderate traumatic brain injury. On assessing patients 3week post cerebroprotein infusion, amongst Group A, 110 were with mild and 40 were with moderate category of traumatic brain injury. Whereas 90 were with mild and 60 were with moderate category of traumatic injury in Group B. Conclusion: Cerebroprotein hydrolysate infusion has a beneficial effect in managing cases of acute traumatic brain injury and is safe and well tolerated by the patients
Authors and Affiliations
Dr. DuttaluruSeshadri Shekar, Dr. Rohit Reddy Arumalla, Dr. Vimala Ambati, Dr. KesanakurthiSatyanarayana Murthy
Keywords
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- EP ID EP255716
- DOI 10.9790/0853-1609021214
- Views 73
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