EFFECT OF CHITOSAN ON THE RHEOLOGICAL PROPERTIES OF HYDROGELS BASED ON SODIUM CARBOXYMETHYLCELLULOSE
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2015, Vol 0, Issue
Abstract
The aim of the study was to evaluate the effect of changing the concentrations of chitosan on the rheological properties of the obtained formulation. Hydrogels were prepared with 1% hydrocortisone containing 4% sodium carboxymethylcellulose with the addition of chitosan, propylene glycol-1,2 or polyethylene glycol 400 and glycerol or paraffin. The concentration of chitosan and excipients affects the rheological properties of gels and the pharmaceutical availability of hydrocortisone. Increasing the concentration of chitosan have influence on increasing the viscosity, hardness, and cohesiveness of the tested gels.
Authors and Affiliations
Maria Szcześniak, Bożena Grimling, Janusz Pluta, Jan Meler
Keywords
Related Articles
- EP ID EP73352
- DOI 10.15259/PCACD.20.25
- Views 78
- Downloads 0
STUDY OF THE INFLUENCE OV UV RADIATION ON BIODEGRADABLE BLENDS BASED ON CHITOSAN AND STARCH
The biodegradable blends of chitosan and starch with different component ratios were prepared by casting method. Obtained thin films were UV-irradiated (λ = 254 nm) and changes in chemical structure were monitored using...
INFLUENCE OF THE INTERMOLECULAR INTERACTION ON PHYSICO-CHEMICAL PROPERTIES OF CHITOSAN/HYALURONIC ACID BLENDS
In the present study, the results of viscosity measurements in dilute solutions of chitosan (Ch) with hyaluronic acid (HA) are presented. Chitosan is blended with hyaluronic acid in aqueous 0.1M CH3COOH/0.2M NaCl and 0.3...
PERVAPORATIVE INVESTIGATION OF ETHYL ALCOHOL DEHYDRATION
Pervaporative separation properties of crosslinked chitosan and alginate membrane on ethanol-water mixture at room temperature was studied. The influence of crosslinking agents on the separation properties were discussed...
INFLUENCE OF DIFFERENT CHANGES ON BIOAVAILABILITY OF MEDICINE CHITOSANS ANTIPHLOGISTIC DRUGS
The increased adsorption of anti-inflammatory drugs on polymer with pH increased from 7.6 to 8.0 may be explained by the swelling properties of chitosan, which increase with increasing environmental pH to alkaline levels...
BIOLOGICAL PROPERTIES OF THERMOSENSITIVE CHITOSAN GELS CONDITIONING IN WATER
In this paper the properties of thermosensitive chitosan hydrogels prepared with the use of chitosan salz (chloride and lactate) and -glycerophosphate are presented. Biological studies were carried out on thermogels wit...