PLA MICROGRANULES USED AS CARRIERS OF ACTIVE SUBSTANCES PREPARED BY EMULSIFICATION IN CHITOSAN SOLUTION
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2009, Vol 0, Issue
Abstract
The aim of research was the preparation of poly(lactide) and chitosan composite of spherical structures by emulsyfication of both polymers solutions. This resulted in fabrication of PLA microstructures (mPLA) suspended in chitosan acetate. Obtained through coacervation, hybrid structures in the form of beads were freeze dried, which led to final composite matrices. The interactions between oposite charged biopolymers in the composite was confirmed by SEM analysis. Studies of share distribution of mPLA microstructures as well as kinetics of beads swelling and ibuprofen release to the gastro-intestinal track environment were conducted.
Authors and Affiliations
Jacek Balcerzak, Maria Mucha
Keywords
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