RESEARCH OF PHARMACEUTICAL PROPERTIES OF HYDROPHILIC POWDERS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2014, Vol 0, Issue
Abstract
Hydrophilic powders passing gels containing lactic acid complexed with chitosan at a stoichiometric ratio of 1:1 and 8:1 revealed pH ranged from 3.92 to 4.44 and 2.36 to 2.84. Rheological studies demonstrated that the research gels obtained from powders possess the dynamic viscosity ranging from 53 to 398 mPa.s for the 1:1 stoichiometric ratio in the complex and from 19 to 242 mPa.s for the 8:1 ratio. As a result of the research, preparations with different pH values, including physiological range, were obtained. Powders show that the adhesion of the gel covering the surface of the apparatus simulates the conditions in the vagina. The gels obtained from the powders were characterised by the specific dynamic viscosity and possess the work of adhesion. The results obtained in the experimental studies proved that it is possible to produce a preparation with optimal pharmaceutical and application properties.
Authors and Affiliations
Katarzyna Małolepsza-Jarmołowska
Keywords
Related Articles
- EP ID EP73404
- DOI 10.15259/PCACD.19.09
- Views 116
- Downloads 0
THE INFLUENCE OF CHITOSAN DEACETYLATION DEGREE ON REACTIVE BLACK 5 SORPTION EFFICIENCY FROM AQUEOUS SOLUTIONS
In the paper sorption capacity of chitosan having a deacetylation degree DD=75%, DD=85% and DD=90% relatively to the Reactive Black 5 were compared. Studies on the effectiveness of the dye sorption were carried out in a...
SYNTHESIS OF SILVER NANOPARTICLES IN A CHITOSAN SOLUTION
In the present study silver nanoparticles were obtained using the ability of chitosan to form chelate compounds with metal ions and taking advantage of its reducing properties. The reduction process was conducted at the...
PHARMACEUTICAL ASSESSMENT OF THERMOSENSITIVE HYDROPHILIC GELS WITH POLYVINYL PYRROLIDONE K-30 CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN
Gels containing lactic acid complexed with chitosan at a stoichiometric ration 1:1 and 2:1 and 5 - 25% content of polyoxyethylene glycol 200 are able to move from 25 to 30 cm. Measurements performed in a biopharmaceutica...
WETTING PROPERTIES OF CHITOSAN-MODIFIED AND PLASMA-TREATED PEEK SURFACES
In this paper, the wettability of chitosan/phospholipid (1,2-dipalmitoyl-sn-glycero-3-phosphocholine – DPPC), chitosan/lipid (cholesterol – Chol) and chitosan/protein (cyclosporine A – CsA) films on air plasma activated...
INFLUENCE OF HYDROPHILIC POLYMERS ON THE PROPERTIES OF GYNECOLOGICAL POWDERS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN
Tested impact of polyvinyl alcohol, dextrane and calcium alginate for the properties of the powders containing poloxamer 407 and lactic acid complexed with chitosan. For researches was prepared formulations with differen...