RESEARCH OF PHARMACEUTICAL PROPERTIES OF HYDROPHILIC POWDERS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2014, Vol 0, Issue
Abstract
Hydrophilic powders passing gels containing lactic acid complexed with chitosan at a stoichiometric ratio of 1:1 and 8:1 revealed pH ranged from 3.92 to 4.44 and 2.36 to 2.84. Rheological studies demonstrated that the research gels obtained from powders possess the dynamic viscosity ranging from 53 to 398 mPa.s for the 1:1 stoichiometric ratio in the complex and from 19 to 242 mPa.s for the 8:1 ratio. As a result of the research, preparations with different pH values, including physiological range, were obtained. Powders show that the adhesion of the gel covering the surface of the apparatus simulates the conditions in the vagina. The gels obtained from the powders were characterised by the specific dynamic viscosity and possess the work of adhesion. The results obtained in the experimental studies proved that it is possible to produce a preparation with optimal pharmaceutical and application properties.
Authors and Affiliations
Katarzyna Małolepsza-Jarmołowska
Keywords
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- EP ID EP73404
- DOI 10.15259/PCACD.19.09
- Views 97
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