Effect of chlorpyrifos on the profile of subpopulations immunocompetent cells B, T and NK in in vivo model
Journal Title: Roczniki Państwowego Zakładu Higieny - Year 2014, Vol 65, Issue 4
Abstract
Background. Current studies have indicated many environmental factors, such as pesticides, that cause immune system disorders through inducing changes in humoral and cellular responses thereby increasing the risk of contracting infectious diseases and cancer. The literature suggests that low exposures to certain organophosphorus pesticides stimulate the immune system, whilst high exposures result in decreased function. Precise mechanisms for the fall in immunocompetence are often unclear, however it can be predicted that the intimate interaction between the nervous and immune systems can potentially lead to toxicity. Objectives. To determine the effects of organophosphorus pesticide, chlorpyrifos that is often used in Poland, on selected immunological responses, such as immune-competent cell proportions formed experimentally in-vivo by cells of Wistar rats during subchronic exposures after 45 and 90 days. Materials and Methods. The test was carried out on ten male and ten female Wistar rats in each of three test groups, who received 3 chlorpyrifos doses for 90 days intragastrically, according to OECD guidelines (No. 401). Two control groups were given olive oil. After completion, the animals were deeply anaesthetised by a mixture of ketamine (Vetaketam) and xylazine (Vetaxym). Immuno-competent cells were profiled by a commercial monoclonal antibody method. In order to measure the dynamics of any changes, the aforementioned immunological responses were investigated after 45 days using the same procedures for obtaining the relevant biological test material. Results. Test animals exposed to chlorpyrifos had altered number of white bood cells which were either increased or decreased relative to controls after 45 and 90 days for all exposure levels used. Conclusions. The study demonstrated changes in white-blood cell (lymphocyte) response profiles, reflecting an immunomodulation although such changes were equivocal, where both suppression and stimulation were observed.
Authors and Affiliations
J. Noworyta-Glowacka, M. Beresińska, R. Bańkowski, B. Wiadrowska, J. K. Ludwicki
Keywords
Related Articles
- EP ID EP246804
- DOI -
- Views 87
- Downloads 0
Allium sativum: facts and myths regarding human health
Garlic (Allium sativum L. fam. Alliaceae) is one of the most researched and best-selling herbal products on the market. For centuries it was used as a traditional remedy for most health-related disorders. Also, it is wid...
Eating behaviours of middle- and secondary-school pupils from the Upper Silesian region in Poland
Background. Eating behaviours of school-aged youth condition their emotional and psychophysical development. Moreover, they influence the effectiveness of learning and affect one’s health and the quality of life at older...
Physical activity and associated socio-demographic factors in adolescents from the eastern region of Poland
Background. The introduction and maintenance of healthy habits in the field of physical activity at the early stage of life is particularly important for public health. With increasing of public awareness in physical act...
Association between self-efficacy and dietary behaviours of American football players in the Polish clubs in the light of dietary recommendations for athletes
Background. Personality traits associated with one’s health beliefs and expectations constitute a determinant of dietary behaviours. Objective. The aim of the study was to analyse the dietary behaviours of young America...
Dietary sources of lutein in adults suffering eye disease (AMD/cataracts)
Background. Epidemiological studies indicate that by consuming 6-14 mg lutein daily, the risk of acquiring eye diseases like age-related macular degeneration (AMD) or cataracts becomes reduced. Their symptoms can also by...