Effect of Clonidine as an Adjuvant to Bupivacaine in Epidural Anaesthesia
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 6
Abstract
Epidural anaesthesia is the most preferred anaesthetic technique for lower abdominal and lower limb surgeries. The aim of the present study was to compare Clonidine as an adjuvant with Bupivacaine in epidural anaesthesia with respect to onset and duration of sensory and motor block, duration of analgesia hemodyanamic changes and adverse effects. The study was carried out on 60 patients of either sex ,aged 18 to 65 years of age and belonging to ASA Grade I & II physical status, scheduled for surgery under epidural anaesthesia. Patients were divided into two groups with 30 patients each. Group I was given 20ml 0.5% plain bupivacaine + 0.5ml saline and Group II was given 20ml0.5% plain bupivacaine + 2µg/kg clonidine.Sensory block was assessed by pin prick and motor block was assessed by modified bromage scale. Data were compared using paired t-test, analysis of variance (ANOVA) and chi-square test. The time of sensory onset upto T10 was shorter in group II (9.82±3.10 min) as compared to group I (15.02±2.6 min).The time of motor block onset to bromage 3 was shorter in group II (17.80±4.08 min) as compared to group I (20.36±3.4 min).The time of motor block regression to bromage 0 was longer in group II (226.42±26.17 min) as compared to group I (152±12.2 min).The time of sensory block regression and the duration of analgesia was also longer in group II. Thus clonidine seems to be a good choice as an adjuvant with bupivacaine in epidural anaesthesia. Keywords: Epidural, Clonidine, Bupivacaine, Pin prick, Modified Bromage scale, Analgesia.
Authors and Affiliations
Geeta Karki, Vishwadeep Singh, Priyank Srivastava, H. S. Nanda
Keywords
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