Effect of CMPA (Cow’s Milk Protein Allergy) and Recurrent Respiratory Infections in Children with Down’s Syndrome
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 3
Abstract
Introduction: Down syndrome (DS) is the most prevalent genetic disorder with intellectual disability (ID) in India. It is associated with various disorders related to heart, respiratory and gastrointestinal tract. Cow milk protein allergy (CMPA) is commonly seen in down syndrome children. This CMPA seems to be responsible for increase in respiratory infection is found in children with Down syndrome compared to other children. In this study we have tried to investigate the correlation between incidences of respiratory infection after removing cow milk in children with Down syndrome. Study aimed to investigate the effect of cow milk protein allergy and its relation to the frequency of respiratory infections occurring in children with Down Syndrome. Material and Methods: Children aged between 1 – 10 years with Down syndrome confirmed by karyotyping or genetic analysis were chosen for the study. Children should have cow cow milk in their routine diet in relation to respiratory symptoms and episodes were noticed before and after the consumption and removal of the cow milk in these children. Blood tests were performed to confirm the immunological profile. Results: Fewer incidences of respiratory infections is seen in children with Down Syndrome, when the cow milk is removed from the regular diet. High incidence of IgA and IgE for cow’s milk protein were seen in children with Down Syndrome. Infections were found to be significantly less in number during the course of cow milk free diet. Conclusion: Children with high IgA and IgE levels are more susceptible to the cow milk protein allergen which might be the reason for recurrent infection which suggests that removal and modification of diet will help in the betterment of the children.
Authors and Affiliations
Priya Chandrasekhar
Keywords
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