Assessment of Efficacy of Amlodipine with Cilnidipine in Hypertensive Patients: A Comparative Study
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 4
Abstract
Introduction: The major problem encountered in treatment patients of hypertension and diabtetic patients with hypertension is controlling their Systolic blood pressure (SBP) and Diastolic blood pressure (DBP). One of the calcium channel blockers (CCBs) with outstanding pharmacokinetic and pharmacodynamic profile is amlodipine. Cilnidipine is the newer generation of CCB that also inhibits sympathomimetic activity. Hence; we undertook the present study to evaluate the antihypertensive efficacy of amlodipine and cilnidipine in treating patients of hypertension. Material and methods: The present study included assessment of 90 hypertensive patients that were undergoing treatment for the same. Auscultatory method with standard mercury sphygmomanometer was used for the measurement of the blood pressure. All the 90 patients were divided into two study groups with 45 patients in each group. The first group comprised of patients who were prescribed amlodipine 5–10 mg/day while the other group included patients who were given cilnidipine 10–20 mg/day orally as a treatment protocol for hypertension. The mean values of Systolic blood pressure (SBP) and Diastolic blood pressure (DBP) during check up were recorded and assessed. All the results were analyzed by SPSS software. Results: A total of 90 patients were included in the present study. The mean SBP in the Amlodipine group patients and in the cilnidipine group patients was 139.1 and 144.2 mm of mercury respectively. The mean DBP in the Amlodipine group patients and in the cilnidipine group patients was 80.2 and 85.3 mm of mercury respectively. Non-significant results were obtained while comparing the mean SBO and DBP among patients of the two study groups. 28 patients in amlodipine group and 5 patients in the cilnidipine group showed the presence of edema. Conclusion: In hypertensive patients, equal efficacy is exhibited by both amlodipine and cilnidipine in reduction of blood pressure.
Authors and Affiliations
K. Anantha Babu
Keywords
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