Effect of cold stress on heart rate and blood pressure in healthy offspring with and without parental history of type2 diabetes mellitus
Journal Title: Indian Journal of Clinical Anatomy and Physiology - Year 2018, Vol 5, Issue 2
Abstract
Introduction The cold pressor test which is considered to be a sympathoexcitatory maneuver is a simple noninvasive and validated test of sympathetic activation The heart rate and blood pressure responses to CPT could be used as indicators of global sympathetic activation and thus of cardiac status and autonomic function Autonomic nervous system dysfunction at the subclinical level seems to be the predisposing condition that occurs far earlier before developing an overt diabetic conditionAims To evaluate the cardiac autonomic status and its reactivity among healthy offspring with and without parental history of Type2 Diabetes Mellitus T2DM To Compare the autonomic reactivity by recording Heart Rate HR and Blood pressure during and after CPT between healthy offspring with and without parental history of T2DMMaterials and Methods This study consists of 40 healthy male subjects with family history of T2DM cases and 40 healthy male subjects without family history of T2DM controls in the age group of 1825 years HR and BP during and after CPT were compared between cases and controlsResults Student t test two tailed independent has been used to find the significance of study parameters on continuous scale between two groups HR response to post CPT showed significant differences between two groups across all the time points Controls showed higher HR than cases at all the time points However the reduction of HR with time was more gradual in controls The graphical representation of SBP changes after CPT shows fluctuation among cases before it reaches the stable value whereas in controls the decrease was at constant level Conclusion The results suggest there was altered autonomic reactivity to physical stress among the offspring with parental history of T2DM when compared to their counterparts and hence this points towards the fact that they are at a risk of developing future autonomic dysfunction and cardiovascular complicationsKeywords Cold Pressor test CPT Type2 Diabetes Mellitus T2DM Heart Rate HR Systolic Blood Pressure SBP and Diastolic Blood Pressure DBP
Authors and Affiliations
Vivek P. , Arifuddin M. K.
Keywords
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- EP ID EP475862
- DOI 10.18231/2394-2126.2018.0045
- Views 46
- Downloads 0
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