Effect of dexmedetomidine infusion on stress induced blood glucose levels and intraoperative sevoflurane requirement
Journal Title: Indian Journal of Clinical Anaesthesia - Year 2018, Vol 5, Issue 4
Abstract
Introduction Dexmedetomidine has been shown to blunt the stress response to surgery and reduce the consumption of inhalational anaesthetic agents Hence we designed this study to observe the effects of IV Dexmedetomidine infusion on stressinduced blood glucose levels and intra operative Sevoflurane requirement during laparoscopic surgeryMaterials and Methods Sixty patients between the ages of 1860 years of either gender ASA Grade I II posted for elective laparoscopic surgical procedures under general anaesthesia were divided into two groups of 30 each Group D received loading dose of Inj Dexmedetomidine at 1gkg diluted to 50 ml and given over 10 minutes followed by maintenance with 05gkghour till the end of surgery Group P received similar volume of normal saline Anaesthesia was maintained with Nitrous oxide in oxygen 5050 and Sevoflurane keeping BIS 40 60 Serial blood glucose levels sevoflurane requirement by Dions method extubation time sedation score and adverse effects were observed The data was analyzed using student t testResults Blood glucose levels at first hour post operatively in group P and in group D were 1367630 mgdl and 1038828 mgdl respectively PConclusion IV Dexmedetomidine infusion was effective in attenuating stress induced blood glucose levels and it also reduced Sevoflurane requirement without affecting the time for extubationKeywords Dexmedetomidine Stress induced blood glucose levels Dions method Sevoflurane consumption
Authors and Affiliations
Yasha V Kameshwar, M R Upadhyay
Keywords
Related Articles
- EP ID EP476522
- DOI 10.18231/2394-4994.2018.0110
- Views 109
- Downloads 0
To compare intravenous paracetamol with tramadol given pre-emptively for intraoperative and postoperative analgesia- A randomized controlled trial
Introduction: The recommended approach for postoperative pain management is to initiate the treatment with analgesics such as paracetamol, NSAIDS, and aspirin followed by adjunctive use of opioids to treat more acute pai...
Comparative study between oral midazolam and oral ketamine as preanaesthetic medication in paediatric patients undergoing elective surgery: a randomized double blind study
Introduction Prime objective of anaesthesiologist is to minimize adverse psychological and physiological effects of anaesthetic technique Premedication causes sedation and reduction of anxiety during separation from pare...
Mechanical ventilation in trauma-the first 24 hours: A retrospective analysis
Introduction Warfare injuries are a special subset of trauma involving complex injury mechanisms and extensive tissue damage Theses mechanisms may lead to significant deterioration in lung function even in the absence of...
Hip replacement in a patient of sickle cell disease: an anaesthetic challenge
Majority of surgical procedures in patients with sickle cell disease are a result of the disease process itself and require intervention for either treatment or prevention of certain complications. Avascular necrosis of...
A prospective randomized double blind study to compare the effects of dexmedetomidine and fentanyl on intubating conditions during awake fiberoptic bronchoscopy guided intubation
Introduction Various drugs have been used for sedation to provide adequate intubating conditions during awake fiberoptic intubation AFOI but these drugs may cause excessive sedation followed by respiratory depression whi...