Effect of dexmedetomidine infusion on stress induced blood glucose levels and intraoperative sevoflurane requirement
Journal Title: Indian Journal of Clinical Anaesthesia - Year 2018, Vol 5, Issue 4
Abstract
Introduction Dexmedetomidine has been shown to blunt the stress response to surgery and reduce the consumption of inhalational anaesthetic agents Hence we designed this study to observe the effects of IV Dexmedetomidine infusion on stressinduced blood glucose levels and intra operative Sevoflurane requirement during laparoscopic surgeryMaterials and Methods Sixty patients between the ages of 1860 years of either gender ASA Grade I II posted for elective laparoscopic surgical procedures under general anaesthesia were divided into two groups of 30 each Group D received loading dose of Inj Dexmedetomidine at 1gkg diluted to 50 ml and given over 10 minutes followed by maintenance with 05gkghour till the end of surgery Group P received similar volume of normal saline Anaesthesia was maintained with Nitrous oxide in oxygen 5050 and Sevoflurane keeping BIS 40 60 Serial blood glucose levels sevoflurane requirement by Dions method extubation time sedation score and adverse effects were observed The data was analyzed using student t testResults Blood glucose levels at first hour post operatively in group P and in group D were 1367630 mgdl and 1038828 mgdl respectively PConclusion IV Dexmedetomidine infusion was effective in attenuating stress induced blood glucose levels and it also reduced Sevoflurane requirement without affecting the time for extubationKeywords Dexmedetomidine Stress induced blood glucose levels Dions method Sevoflurane consumption
Authors and Affiliations
Yasha V Kameshwar, M R Upadhyay
Keywords
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- EP ID EP476522
- DOI 10.18231/2394-4994.2018.0110
- Views 112
- Downloads 0
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