Effect of Dexmedetomidine Versus Fentanyl on Haemodynamic Response to Patients Undergoing Elective Laparoscopic Surgery: A Double Blinded Randomized Controlled Study

Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 4

Abstract

Introduction: Dexmedetomidine, an a2 agonist, can be used as an adjuvant in general anaesthesia as it attenuates the stress response to various noxious stimuli and helps in maintaining the perioperative haemodynamic stability along with sedation and not causing any significant respiratory depression in the postoperative period. Aim: To study the difference in haemodynamic responses of dexmedetomidine and fentanyl in patients undergoing laparoscopic surgery. Materials and Methods: Sixty patients were divided into two groups of 30 each randomly. In Group F, fentanyl 0.5 μg/kg as loading dose over 10 minutes prior to induction followed by 0.2-0.7 μg/kg/hr as maintenance dose and in Group D, Dexmedetomidine 0.5 μg/kg as loading dose over 10 minutes prior to induction followed by 0.2 μg/kg/hr-0.7 μg/kg/hr as maintenance dose till surgery was over. Haemodynamic variables and Visual Analogue Scale (VAS) scores were recorded continuously. Postoperative sedation and recovery were assessed by modified Ramsay sedation score. Results: Systolic Blood Pressure (SBP) fell by 9% in Group-D as compared to no fall in Group F during intubation. After intubation, 9% increase is seen in Group D v/s 19% in Group F. During the period of pneumoperitoneum upto 5 minutes post extubation, the SBP in Group D was significantly lower as compared to Group F rest duration, the difference was not significant between both groups. Heart Rate (HR) remained stable throughout the study except at laryngoscopy when it rose. Heart rate was similar in both groups at intubation, decreased by 3.51% in Group D as compare to 11.11% rise in Group F. Post intubate on, heart rate fell by 2% in Group D vs 15% rise in Group F. Diastolic Blood Pressure (DBP) remained higher than baseline than throughout the study. After intubation, 3% higher in Group D where as 15% in Group F increase was seen. In intraoperative period the difference between both groups was not significant. There was significant difference between two groups at 10 minutes, 45 minutes of pneumoperitoneum. End Tidal CO2 (ETCO2 ) was similar in both groups. Conclusion: Dexmedetomidine is better drug as compared to fentanyl for maintaining the haemodynamic response during intubation and intraoperative period.

Authors and Affiliations

Lovina Neil, Ashok Patel

Keywords

Related Articles

Gender Determination of an Individual by Scapula using Multi Detector Computed Tomography Scan in Dakshina Kannada Population-A Forensic Study

ABSTRACT Introduction: Gender is the most vital segment of the biological characteristics which can be evaluated from the skeleton because of the marked sexual dimorphism of bone segments. The bone examined in present st...

Laparoscopic versus Open Repair of Para-Umbilical Hernia- A Prospective Comparative Study of Short Term Outcomes

Introduction: Para-Umbilical Hernia (PUH) is one of the most common surgical problems. Since the prosthetic repair has become the standard of practice for inguinal hernia management, the same has been adapted for para-um...

Successful Rapid Desensitization of Two Teenagers with Rituximab Hypersensitivity

ABSTRACT Rituximab is one of the monoclonal antibodies that is used in the management of malignancies and auto-inflammatory disorders. Rituximab causes Hypersensitivity Reactions (HSRs) during infusions. The delay of tre...

Comparison of Polymerase Chain Reaction and Immunohistochemistry Assays for Analysing Human Papillomavirus Infection in Oral Squamous Cell Carcinoma

Introduction: Polymerase Chain Reaction (PCR) and Immunohistochemistry (IHC) are two well-known techniques used for the diagnoses of genetic diseases, tumours and different pathogens. PCR basically amplify regions of DNA...

Crossed Fused Renal Ectopia showing Pelviureteric Junction Obstruction with Single Ureter and Single Renal Artery

ABSTRACT Crossed fused renal ectopia is a rare anomaly remaining asymptomatic by far and detected invariably as either incidental finding or in view of pre-existing kidney disease. We report a case of crossed fused renal...

Download PDF file
  • EP ID EP338710
  • DOI 10.7860/JCDR/2017/24152.9563
  • Views 98
  • Downloads 0

How To Cite

Lovina Neil, Ashok Patel (2017). Effect of Dexmedetomidine Versus Fentanyl on Haemodynamic Response to Patients Undergoing Elective Laparoscopic Surgery: A Double Blinded Randomized Controlled Study. Journal of Clinical and Diagnostic Research, 11(4), 1-4. https://europub.co.uk/articles/-A-338710