Effect of Dexmedetomine on Haemodynamics and Isoflorane Requirement during Laparoscopic Cholecystectomy
Journal Title: Journal of Pharmaceutical and Biomedical Sciences - Year 2016, Vol 6, Issue 1
Abstract
Minimal access surgery like laparoscopic cholecystectomy has several advantages like less pain, early mobilisation, shorten stay in hospital and better cosmetic results. Due to the haemodynamic response to pneumoperitoneum, laparoscopic procedures are not free from risk. Uses of dexmedetomidine during general anaesthesia attenuate the haemodynamic response of pneumoperitoneum. In this study we evaluate the effect of dexmedetomidine on haemodynamic and the isoflorane requirement. A prospective randomised and double-blind study was conducted in 50 patients by dividing them in two groups. Group C as control (normal saline infusion) and Group D (dexmedetomine infusion) as test. Standard anaesthesia procedure is followed. During anaesthesia bispectral index (BIS) monitoring is done and it was maintained in the range of 40–60 with the titration in the dose of inhalational anaesthetic (isoflorane). Result shows that there is significant haemodynamic stability (P < 0.05) and 70% reduction in the requirement of isoflorane (P < 0.05) in Group D as compared to Group C. BIS was maintained in the range of 40–60. It is concluded that the use of Dexmedetomine results in better haemodynamic and requirement of inhalational anaesthetic can be reduced.
Authors and Affiliations
Rajeev Kumar
Keywords
Related Articles
- EP ID EP184006
- DOI -
- Views 107
- Downloads 0
Efficacy and Tolerability of Fixed Dose Combination Valsartan/Amlodipine to Achieve Blood Pressure Target in Iraqi Hypertensive Patients
Background Fixed dose combinations (FDCs) are one of the options for improving blood pressure (BP) goal attainment. However, it has not been studied previously in Iraqi patients. Objective The aim of the study is to eval...
A Study of Intermediate Syndrome in Organo Phosphorus Compound Poisoning in Rural Area
Poisoning with organophosphorus compounds is one of the commonest forms of poisoning in our country. Patients with organophosphorus poisoning present with the symptoms and signs of acetylcholine excess, which is called a...
Effectiveness of Yoga on Stress among Primigravid Women in Third Trimester
Pregnancy and childbirth are the events that touch nearly every aspect of the human experience. Pregnancy brings both psychological and physical changes to women. It can be time of potential stress for many women. The st...
Repair of Articular Cartilage Defect Using NaOH-treated PLGA-[ASP-PEG]n Scaffolds Loaded Adipose-derived Stem Cells and Bone Morphogenetic Protein-2
The aim of this study was to evaluate the feasibility of NaOH-treated PLGA-[ASP-PEG]n scaffolds with bone morphogenetic protein 2 (BMP-2) modified adipose derived mesenchymal stem cells (ADSCs) in repairing articular car...
Ensuring the Survival of Pier Abutment: A Case report
Comprehensive treatment planning is an important aspect before actively undertaking the actual treatment procedures, even in similar looking clinical situations. The biomechanics of most commonly used fixed-fixed bridges...