EFFECT OF EDAPHIC FACTORS ON MAJOR SECONDARY METABOLITES OF TINOSPORA CORDIFOLIA AND NEEM GUDUCHI WITH RESPECT TO THEIR IMMUNOMODULATORY EFFECT
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2019, Vol 10, Issue 7
Abstract
Tinospora cordifolia is a requisite medicinal plant, has been used for the treatment of various diseases and has been recommended for improving the immune system mentioned in Ayurveda and other systems of medicine as a monoherbal or polyherbal preparation. Nonetheless, Ayurvedic and other ancient literature reported that Tinospora cordifolia growing on neem plant gives better immunomodulatory activity. The traditional and scientific data comprising immunomodulatory potential, pharmacognostic description, therapeutic uses, phytochemical constitution, of Tinospora cordifolia and neem guduchi using the aqueous extract in the form of satwa has well established. The present study evaluates the comparative immunomodulatory activity using satwa of Tinospora cordifolia and neem guduchi using in-vitro models, for understanding the influence of edaphic factors on biologically active compounds. Evaluation of the immuno-modulatory potential of the guduchi satwa and neem guduchi satwa at the dose of 150 and 300 mg/kg body weight was done in rats; assessment of immunomodulatory activity was carried out by assessment of neutrophil adhesion whereas phytochemical profile was established by HPTLC method. Simultaneously, the correlation between soil factors and medicinally active compound responsible for immunomodulation also studied. In the present study, we have compiled and investigated the active compounds which are immuno-modulator. Results of present studies suggested that neem guduchi satwa was found to be potent immuno-stimulant in a dose-dependent manner when compared with other group and there is no clear correlation between soil factors and medicinally active compound were observed.
Authors and Affiliations
Suresh D. Jagtap et al.
Keywords
Related Articles
- EP ID EP607403
- DOI 10.13040/IJPSR.0975-8232.10(7).3386-94
- Views 64
- Downloads 0
TRIGONELLA FOENUM-GRAECUM L. SEED MUCILAGE-BASE MUCOADHESIVE MICROSPHERES OF DICLOFENAC SODIUM
The study was aimed to discover the properties of Trigonella foenum-graecum L. seed mucilage (TFGSM) in the formulation of mucoadhesive microspheres of diclofenac sodium to prolong the residence time at the site of absor...
FORMULATION AND EVALUATION OF ANTIHYPERTENSIVE BILAYER TABLET
The present research work was carried out to Formulate and evaluation of bilayer tablet dosage form for the treatment of Hypertension. The objective of this study to compare the specific characteristics of Olmesartan Mid...
CYTOTOXIC AND APOPTOGENIC EFFECTS OF A BIOACTIVE FRACTION ISOLATED FROM THE LEAVES OF A TRADITIONAL MEDICINAL PLANT TRIDAX PROCUMBENS
Objective: To investigate the anti-proliferative effects of T. procumbens leaf extracts on the growth of MCF 7, Hep G2 and K562 cells. An attempt was made to partially purify the cytotoxic acetone extract using a bioassa...
RP-UPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION AND FORCED DEGRADATION STUDIES OF ELVITEGRAVIR, COBICISTAT, EMTRICITABINE AND TENOFOVIR DISOPROXIL FUMARATE IN SOLID DOSAGE FORM
A stability indicating method was developed and validated for simultaneous estimation of Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Disoproxil Fumarate (Tenofovir D F) in solid dosage form using RP-UPLC metho...
DOSE DEPENDENT CARDIAC EFFECTS OF DOXORUBICIN IN WISTAR RATS: A BIOCHEMICAL AND HISTOPATHOLOGICAL ANALYSIS
Although doxorubicin is used widely in animal models to induce cardiotoxicity, serial dose-dependent cardiac effects have not been investigated in experimental animal models to date. Therefore, the objective of this stud...