Effect of Essential Phospholipids and Statin on Non Alcoholic Fatty Liver Disease in Rats Induced Periodontitis
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 11
Abstract
NAFLD is the most common form of chronic liver disease, it is the hepatic manifestation of metabolic syndrome. Periodontal disease may helpfully increase the risk of progression from NAFL to NASH. Effective strategies are needed to treat NAFLD and prevent progression to NASH so we conducted this study to investigate the efficacy of EPL and statin on biochemical parameters and histo-pathological finding in rats with NAFLD and periodontitis. Methods: 35 Male rats were divided into 5 groups, group 1:control group, group 2: NAFL, group 3: NAFL with periodontitis, group 4: rats with NAFL and periodontitis received EPL and group 5: rats with NAFL and periodontitis receiving statin after 30 days of treatment blood sample and mandibles were collected for biochemical analysis and histo-pathological findings. Result : group treated with statin significantly elevated (AST, ALT and ɤGGT) and lipid profile while treatment with EPL significantly reduced liver enzymes and lipid profile parameters, both EPL and Statin reduce OPG level and improved bone resorption which confirmed by histological findings. Conclusion: We confirm the efficacy of EPL in accelerating the improvement of biochemical and pathological findings, such as liver function enzymes, lipid profile and bone resorption in rats with NAFLD and periodontitis.
Authors and Affiliations
Nevien M. Ahmed, Ahmed SH. Hashem
Keywords
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