Effect of Ethanolic Extract of Emblica officinalis (Amla) on Glucose Homeostasis in Rats Fed with High Fat Diet
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2017, Vol 6, Issue 3
Abstract
Background: Emblica officinalis contains many biological active components which are found to have some medicinal properties against diseases. Aim and Objectives: To assess hypolipidemic and glucose regulatory actions of Ethanolic Extract of Emblica officinalis (EEO) on High Fat Diet (HFD) fed experimental rats. Material and Methods: Twenty four rats were divided into four groups, having six rats in each group as following; Group I- Control (20% fat); Group II (EEO 100 mg/kg/b w); Group III (30% fat) and Group IV (30% fat + EEO 100 mg/kg/b w). The treatment was continued for 21 days. Gravimetric parameters and lipid profiles of all the groups were measured. Oral Glucose Tolerance Test (OGTT), fasting and postprandial glucose and fasting insulin levels were estimated. Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) was calculated. Statistical analysis was done. Results: Significant alteration in serum lipid profile, fasting and post prandial blood glucose levels and fasting insulin level were observed in rats of Group III fed with high fat diet. Supplementation of EEO improved both of glycemic and lipid profiles in rats of Group IV fed with high fat diet. Conclusion: Results from the study indicate the beneficial role of EEO on dyslipidemia and glucose homeostasis in rats treated with high fat diet.
Authors and Affiliations
Pallavi S Kanthe, Bheemshetty S Patil, Manjunatha R Aithala, Kusal K Das
Keywords
Related Articles
- EP ID EP227309
- DOI -
- Views 116
- Downloads 0
Use of Ketamine in Refractory Bronchospasm- A Study of 20 Cases
Objective: To study the effect of ketamine inpatients of severe wheezing due to bronchiolitiswho are refractory to the standard treatment.Methods: Prospective study including 104 childrenbetween 2 months to 2 years who p...
The Spectrum of Dystrophin Gene Mutations in Duchene Muscular Dystrophy Patients of South-Western Maharashtra in India
Background: Duchenne muscular dystrophy is the most common neuromuscular disease of childhood caused by deletion or point mutations in the dystrophin gene. Though the importance of deletion mutations in the dystrophi...
Could Length and Reduced Diameter of Aberrant Renal Artery be Attributed to Significant Reno-vascular Hypertension in the Absence of Stenosis?
Hypertension depends upon various factors such as resistance, pressure difference viscocity, caliber and length of a vessel according to Hagen–Poiseuille law. Length of a vessel is one of the important causes of hyperten...
Speciation and Biofilm Production of Coagulase Negative Staphylococcal Isolates from Clinically Significant Specimens and their Antibiogram
Background: Coagulase Negative Staphylococci (CONS) are increasingly recognized as significant nosocomial pathogens. Their ability of biofilm formation and multiple drug resistance are causing serious human infection...
Prevalence and Intensity of Depression in Mothers of Children withBeta-Thalassemia Major In Taleghani Hospital of Gorgan, Iran
Background: Thalassemia is a chronic disease that itleads to psychological and social problems for parents.Mothers are at markedly increased risk of sufferingfrom psychological distress and depression becausethey usually...