Effect of Ethanolic Extract of Emblica officinalis (Amla) on Glucose Homeostasis in Rats Fed with High Fat Diet
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2017, Vol 6, Issue 3
Abstract
Background: Emblica officinalis contains many biological active components which are found to have some medicinal properties against diseases. Aim and Objectives: To assess hypolipidemic and glucose regulatory actions of Ethanolic Extract of Emblica officinalis (EEO) on High Fat Diet (HFD) fed experimental rats. Material and Methods: Twenty four rats were divided into four groups, having six rats in each group as following; Group I- Control (20% fat); Group II (EEO 100 mg/kg/b w); Group III (30% fat) and Group IV (30% fat + EEO 100 mg/kg/b w). The treatment was continued for 21 days. Gravimetric parameters and lipid profiles of all the groups were measured. Oral Glucose Tolerance Test (OGTT), fasting and postprandial glucose and fasting insulin levels were estimated. Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) was calculated. Statistical analysis was done. Results: Significant alteration in serum lipid profile, fasting and post prandial blood glucose levels and fasting insulin level were observed in rats of Group III fed with high fat diet. Supplementation of EEO improved both of glycemic and lipid profiles in rats of Group IV fed with high fat diet. Conclusion: Results from the study indicate the beneficial role of EEO on dyslipidemia and glucose homeostasis in rats treated with high fat diet.
Authors and Affiliations
Pallavi S Kanthe, Bheemshetty S Patil, Manjunatha R Aithala, Kusal K Das
Keywords
Related Articles
- EP ID EP227309
- DOI -
- Views 77
- Downloads 0
Assessment of Knee Joint Proprioception in Weight Bearing and in Non-Weight Bearing Positions in Normal Subjects
Background: Assessment of proprioception isvaluable for identifying proprioceptive deficits.There are several methods to assess the proprioception.Joint position sense can be assessedin weight bearing (WB) and non weight...
Dyskeratosis Congenita Associated Non-Specific Interstitial Pneumonia
Dyskeratosis Congenita (DC) is a rare inherited disorder of ectodermal dysplasia. It consists of a classical mucocutaneous triad of abnormal skin pigmentation, nail dystrophy and leukoplakia. Pulmonary disease is seen in...
Multifocal Carcinoma of Oral Cavity: A Case Report
Oral Carcinoma is most common among several other cancers in our country (over 40%). The most causative factor is tobacco in various forms. It is very rare to have multiple foci or centres for cancer in oral cavity. T...
Effect of Kangaroo Mother Care on Growth and Morbidity Pattern in Low Birth Weight Infants
Background: Kangaroo Mother Care (KMC) is dened as skin-to-skin contact between a mother and her newborn baby derived from practical similarities to marsupial care giving, proximately exclusive breastfeeding and ear...
Sushruta: Foundation for Surgical Practice
Sushruta was an ancient Indian surgeon (600 B.C.) who resided in Varanasi.The teachings and work of Sushruta is compiled in a treatise called Sushruta Samhita (Sushruta's compendium), which is believed to be a part o...