EFFECT OF ETHANOLIC EXTRACT OF GLYCYRIZZA GLABRA AGAINST STEREPTOZOTOCIN AND HIGH FAT DIET INDUCED DIABETES AND HYPERLIPIDEMIA
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 4
Abstract
Objective: To study the effect of ethanolic extract of Glycyrrhiza glabra against streptozotocin and high-fat-diet-induced diabetes and hyperlipidemia.Methods: The present study was conducted on a 14 d model in which Glycyrrhiza glabra extract was given to Streptozotocin (STZ; 50 mg/kg; i. p.) induced diabetic rats fed with high fat diet (HFD), and its protective effect has been studied. The antihyperlipidemic and antihyperglycemic effects have been evaluated on the basis of physical, biochemical as well as histomorphological parameters.Results: The Glycyrrhiza glabra extract pre-treated group showed a significant decrease in biochemical parameters like Total cholesterol (TC), Triglyceride (TG), High-density lipoprotein (HDL), Lactate dehydrogenase(LDH), Alanine transaminase (ALT) compared with D-HFD group (p<0.01). The pre-treated groups also showed significant protection in physical parameters as compared to D-HFD group (p<0.01) which was also confirmed by histopathological studies. All these results were compared and found to be similar with two standard drugs metformin (500 mg/kg) and atorvastatin (10 mg/Kg).Conclusion: This study concluded that alcoholic extract of Glycyrrhiza glabra (500 mg/kg) has significant antidiabetic and antihyperlipidemic potential against streptozotocin and high-fat diet induced diabetic hyperlipidemic rats comparable to the clinically used drugs.Keywords: Atherosclerosis, Diabetic hyperlipidemia, Diabetes mellitus, Hyperlipidemia, Lipid profile, Streptozotocin
Authors and Affiliations
Arshiya Shamim, Tarique Mahmood, Mohd. Mukeem, Hefazat H. Siddiqui, Paramdeep Bagga, Hina Firdaus, Supriya Roy
Keywords
Related Articles
- EP ID EP577727
- DOI -
- Views 74
- Downloads 0
BACTERIAL AGGLUTINATION BY A LECTIN FROM THE LEAVES OF THE MEDICINAL PLANT, PIMENTA DIOICA (L.) MERR
Objective: The current investigation involves the purification, characterization of the lectin from the leaves of Pimenta dioica (L.) Merr. (Myrtaceae) a medicinal plant, and its application in bacterial typing.Methods:...
EFFECT OF TAMSULOSIN A SELECTIVE α1-ANTAGONIST ON GLUCOSE HOMEOSTASIS IN RATS
Objective: To assess the effect of tamsulosin (α1-antagonist) on blood sugar and adrenaline levels in rats.Methods: Wistar rats were divided in to four groups (n=6), Group-I (Normal control) administered normal saline...
PHARMACOKINETIC STUDIES OF NEW SILVER-BASED COMPLEX
Objective: Investigation of pharmacokinetics parameters of the new silver-based compound of general formula C6H19Ag2N4LiO6S2, called “Argosilâ€, with high antiviral activity.Methods: Water solution of complex administ...
A NEW HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHIC METHOD DEVELOPMENT AND VALIDATION OF DAPAGLIFLOZIN IN BULK AND TABLET DOSAGE FORM
ABSTRACT Objective: To develop a new simple, selective and precise high-performance thin layer chromatographic method for determination of Dapagliflozin (DAPA) in bulk and tablet dosage form Methods: The present study...
IMPACT OF GERANIOL ON CYCLOPHOSPHAMIDE PROVOKED CARDIOTOXIC PROPERTIES–AN IN VIVO STUDY
Objective: Toxicity profiles of diverse anti-neoplastic drugs are extensively documented in past decades and the protective role of natural products against such toxic drugs plays a vital role in the evolution of chemopr...