Effect of ethanolic extract of Piper nigrum Linn. fruits on pharmacodynamics of atorvastatin in rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2013, Vol 2, Issue 1
Abstract
Herb-drug interaction about oral antihyperlipidemic drugs is a challenging concept, since the consumption of food and other herbal drugs is not documented in patient’s profile. With this aspect, the present study was designed to investigate the possible effect of Ethanolic extract of Piper nigrum Linn. fruits on Atorvastatin an oral antihyperlipidemic drug. The study was carried out to investigate the pharmacodynamics of atorvastatin (AT) alone, and in combination with Ethanolic extract of Piper nigrum Linn. fruits and Isolated Piperine in hyperlipidemic rats. The standard cholesterol diet was used to induce hyperlipidemia in Wister rats. The blood samples were collected (on 1st and 8th day) from AT alone and in combination with Extract (100mg/kg) treated and piperine (10mg/kg) treated groups and were analyzed for various lipid profiles. Atorvastatin caused a marked reduction in the lipid profiles in hyperlipidemic rats. The combination of AT and Piper nigrum Linn. fruits in hyperlipidemic rats produced a significant change in lipid profiles (pharmacodynamics). In this study, we investigated the effect of Ethanolic extract of Piper nigrum Linn. fruits on the efficacy of Atorvastatin (substrate for CYP3A4) in rats. These results suggest Piper nigrum Linn. fruits ingestion increases the efficacy of Atorvastatin by inhibiting intestinal CYP3A4 enzyme in albino wistar rats.
Authors and Affiliations
Md. Parvez Md. Parvez
Keywords
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