Effect of Extracorporeal Unfractionated Heparin on Hematological and Electrolyte Markers in Hemodialyzed Patients
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2014, Vol 4, Issue 9
Abstract
End-Stage renal disease is the final stage of chronic kidney disease (CKD), which can be managed by hemodialysis (HD), peritoneal dialysis, or renal transplantation. This study was conducted to investigate the changes in hematological and electrolyte markers that occur pre and post hemodialysis using unfractionated heparin (UFH) to prevent extracorporeal circuit clotting. Fifty patients with end stage renal failure (22 males, 28 females), aged between 15-78 years, maintained on long-term hemodialysis at the hemodialysis center in Sulaimani city during the period between February 20th 2013 and July 15th 2013 were enrolled in the present study. All patients provided written informed consent. The results of the hematological and electrolyte parameters measured pre and post hemodialysis were not significantly changed. No significant reduction in Hb level has been reported after dialysis compared to the pre-dialysis level. There were non-significant change in PTT, PT, and platelets count values in post-dialysis, which were not affected by the extracorporeal UFH. Although serum calcium and sodium levels were not significantly affected, serum potassium was significantly decreased in post hemodialysis states compared with pre-dialysis levels. This study revealed that extracorporeal use of UFH did not affect the hematological and electrolyte parameters post-dialysis in chronic renal failure patients maintained on hemodialysis. Only serum potassium was significantly decreased in post hemodialysis states, but still predictable fluctuations may limit the benefits of the procedure.
Authors and Affiliations
D. H. Ossman , B. H. Marouf , K. H. Ameen
Keywords
Related Articles
- EP ID EP105393
- DOI -
- Views 114
- Downloads 0
Undergraduate Pharmacology: Student’s view – A Questionnaire Study
Pharmacology, a branch of medicine is progressing by leaps and bounds. But the place and status of pharmacology in the medical curriculum is hazy. Medical students decry the way it is taught, its examinations, its useful...
Duloxetine Modulates Vincristine-Induced Painful Neuropathy in Rats
Neuropathic pain is a common and severely disabling state that affects millions of people worldwide. Vincristine-induced peripheral neuropathy models showed mixed sensory motor neuropathy. Duloxetine is the first Food an...
How to Improve Performance in Sport – a Review
The physiology of exercise is the body’s response and adaptation to exercise. The physiological mechanisms that underpin performance are based on three interacting factors. Firstly, the tripartite nature of oxygen uptake...
Antihypertensive Activity of Different Fractions of Tridax Procumbens Crude Aqueous Extract in Wistar Rats
Tridax procumbens is a medicinal plant used in traditional medicine for the treatment of hypertension but only few pharmacological data are available on its antihypertensive effect. The objective of this work was to asse...
Resting Electrocardiogram of Top Athlete: Comparative Study between Football Players and Wrestlers in Senegal
Regular and intensive physical activity induces the "athlete's heart". So we compared the heart function of football players and wrestlers. We conducted a cross-sectional study from 01 April to 31 August 2014, involving...