Effect of Fluoride Toxicity on Some Clinical, Biochemical and Physiological Aspects of Albino Rats
Journal Title: International Journal of Research in Chemistry and Environment (IJRCE) - Year 2012, Vol 2, Issue 1
Abstract
Fluorine is a necessary biological trace element for human health. However, fluoride accumulation leads to cascading effects resulting in altered physiological functions in human being. The objective of the present study was to find out the extend of oxidative damage caused by reactive oxygen species (ROS), generated by the action of fluoride that alter the activities of the enzymes involved in the defense against free radicals and substantially influence the damaging process in brain, kidney and liver. To perform the experiment, healthy albino rats were ingested with fluoride water (5, 10, 15 and 20 ppm) for 60 days for generation of ROS in their body. The data revealed that reduction of body weight and somatic index were observed after the ingestion of 10, 15 and 20 ppm of fluoride water. Higher doses of fluoride water altered the hematological parameters leading to anaemic condition. The percentage of neutrophil is significantly increased (p<0.01) in high fluoride concentration. Total count is also dramatically reduced as compared to control. The antioxidant enzymatic parameters such as Superoxide dismutase (SOD), Glutathione transferase (GST), and catalase decreased significantly (p<0.01) in brain tissues. Loss of activity of some liver enzymes (SGPT and SGOT) indicate the decreased liver activity due to generation of ROS in rat body. The serum protein, Cholesterol and phospholipids were also significantly reduced in all the treatments studied (p<0.01). Glycogen, Cholesterol and Ascorbic acid of liver and heart tissues showed diminished activities following fluoride water treatment. Thus, the present study showed that accumulation of fluoride increases free radical production inhibits the antioxidative enzymes which probably make the tissue more susceptible to biochemical injury. From the study, it can be further concluded that excess fluoride water exposure caused altered blood cells and produce toxic effects on brain, heart and liver
Authors and Affiliations
Samanta Arpita, Bandyopadhyay Bidyut
Keywords
Related Articles
- EP ID EP87608
- DOI -
- Views 228
- Downloads 0
Investigation on Biodecolorization and Molecular Fractionation of Melanoidin Pigment using Cladosporium cladosporioides
This study presents the utilization of Cladosporium cladosporioides as potential fungal strain for the decolorization and molecular fractionation of synthetic melanoidin pigment which is a recalcitrant biopolymer. Si...
Efficacy of a Mix of Fly- Ash and Post Methanated Diluted Distillery Effluent as a Potential Bio- fertilizer: A Case Study on the Biomass of Black Mustard, Brassica nigra
Field studies were conducted to assess the potential of a mix of fly ash and PMDE (post-methanated diluted distillery effluent) both regarded as problematic wastes all over the world. Therefore, both wastes disposal woul...
Electrochemical Studies of Ceftriaxone on Eriochrome Black-T Polymer Film Modified Glassy Carbon Electrode
A novel electrochemical method was developed for the determination of ceftriaxone (CFRX) based on the polymerised film of Eriochrome Black-T (EBT) on the surface of glassy carbon electrode (GCE) in phosphate buffer solut...
[b] Preparation and Properties of Dinuclear Schiff Base Complexes of Co(II) and Ni (II) Via Inter-Complex Reaction[/b]
[i] Homo and hetero dinuclear Schiff base complexes were prepared by inter – complex reaction between Co (II) and Ni (II) complexes of o-vanillin and o-aminophenol. Elemental composition and thermal properties of th...
[b] Isolation and Characterization of Starch from Cultivated and Uncultivated Rubber Seed Flour[/b]
[i]Starches were isolated from both cultivated (Hevea brasiliensis) and uncultivated (Funtumia elastica) rubber seed flours species using 0.2 % NaOH. The starch isolated had high carbohydrate content (82.9-88.9 g/1...