Effect of HbF Level among Different Severity of Sickle Cell Disease
Journal Title: International Blood Research & Reviews - Year 2017, Vol 7, Issue 2
Abstract
Background: Fetal hemoglobin (HbF) can inhibit the deoxygenation induced polymerization of sickle hemoglobin (HbS) that drives the Pathophysiology of sickle cell disease. The aim of this study was to determine fetal Hb level in Sudanese sickle cell disease patients as well as to find out the effect of fetal hemoglobin level on different severity groups. Materials and Methods: This was descriptive cross sectional study included 100 Patients with sickle cell disease diagnosed by Positive sickling test and Hemoglobin electrophoresis. The Patients were attended Sudan sickle cell anemia center (SSCAC), Elobied-Sudan during September 2015 – July 2016. Clinical history was obtained to perform the severity of the disease according to Hedo et al. scoring. Fetal hemoglobin was estimated by Betke's method. Data were analyzed using SPSS software computer program version 21. Results: The mean of HbF level among the studied population was 7.6%. The descriptive analysis showed that, the mean level of HbF in 38 (38%) patients with mild disease was 7.7%, while in 54 (54%) patients with moderate disease the mean level of HbF was 7.6% and the last 8(8%) patients with severe disease showed HbF level 7%. There was no statistical significant differences observed when HbF level was less than 10% (P value = 0.146), while the statistical significant differences was observed among patients with HbF level more than10% (P value = 0.03). Conclusion: The study concluded that Hb F level has no effect in severity of the disease among studied sickle cell patients, unless HbF level more than 10%.
Authors and Affiliations
Ream Elzain Abdelgadir, Mawada Abdelsalam, Abdel Rahim Mahmoud Muddathir
Keywords
Related Articles
- EP ID EP306688
- DOI 10.9734/IBRR/2017/34020
- Views 128
- Downloads 0
Effect of Leaf Essential Oil of Citrus sinensis on Haematological Parameters of Alloxan-induced Diabetic Rats
Aim: The aim of this study was to investigate the effect of leaf essential oil of Citrus sinensis (Rutaceae) on haematological parameters of alloxan – induced diabetic rats. Methodology: Diabetes was induced in albino ra...
Blood Coagulation Tests and Platelets Counts in Diabetic Rats Treated with Ficus sur, Jatropha tanjorensis, Mucuna pruriens and Chromolaena odorata Leaf Extracts
Aim: This study was designed to study the effects of leaves extracts of four indigenous Nigerian medicinal plants namely- Ficus sur, Jatropha tanjorensis, Mucuna pruriens and Chromolaena odorata on platelets counts and b...
Assessment of Thrombolytic Activity of Five Bangladeshi Medicinal Plants: Potential Source for Thrombolytic Compounds
Aim: The aim of our project work was to assess the thrombolytic activity of five common Bangladeshi plant extract in different solvent. Five plants are Geodorum densiflorum (Shankhamul), Pistia stratiotes (Topa Pana), Sm...
Myoglobin Status in Stable Patients with Chronic Kidney Disease
Aim: To measure serum myoglobin concentration in stable patients with chronic kidney disease (CKD) who had not commenced hemodialysis and determine its relationship with cardiovascular risk factors. Study Design: Cross-s...
Appropriateness of Use of Blood Products in Tertiary Hospitals
Aims: This study aimed at evaluating the appropriateness of use of blood products in Northern Philippines and sought to find out if significant differences exist on the appropriateness of use of the blood products among...