Effect of Heavy Alcohol Consumption on Risk of Prostate Cancer among Middle Aged Men in Port Harcourt, Nigeria
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 12
Abstract
Alcohol consumption is a modifiable lifestyle factor that may affect prostate cancer risk. Alcohol alters the hormonal milieu and contains chemical substances such as flavonoids (red wine), which may alter tumour cell growth. The aim of this study was to investigate the effect of alcohol on prostate-specific antigen (PSA) levels of middle-aged men and prostate cancer risk. A total of 45 male volunteers of 40 to 75 years of age participated in the study. All participants completed a questionnaire on life time alcohol consumption. Analysis was done on 20 samples of moderate alcohol consumers, 20 samples of heavy alcohol consumers and 5 samples of non-alcohol consumers which served as the control. The results were analyzed separately for alcohol consumers and non-alcohol consumers and it was significant. A significant increase in the serum level of prostate specific antigen was observed when heavy drinkers were compared with non-drinkers (P = 0.02) and also, when moderate drinkers were compared with nondrinkers (P = 0.01). There was a significant increase in the serum level of prostate specific antigen when moderate drinkers of 60yrs and above were compared with non-drinkers (P=0.02). No significant increase in the serum level of prostate specific antigen was observed when heavy drinkers were compared with moderate drinkers (p = 0.24). These results suggest that both moderate and heavy consumption of alcohol is a contributor to prostate cancer risk and that the risk increases with increase in age
Authors and Affiliations
Brown, Holy
Keywords
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