Effect of Herba Epimedium Extract on Bone Mineral Density and Microstructure in Ovariectomised Rat
Journal Title: Journal of Pharmaceutical and Biomedical Sciences - Year 2016, Vol 6, Issue 5
Abstract
Aim To observe the effects of Herba Epimedium (HE) extract on bone mineral density (BMD) and microstructure in ovariectomised (OVX) rat. Methods A total of 84 female Sprague–Dawley rats of 3-month-old were randomly divided into OVX group (n = 70) and sham group (n = 14). The osteoporotic model was established by ovariectomy. Twelve weeks after ovariectomy, when the osteoporosis (OP) was successfully affirmed by the BMD, the rats in OVX group was randomly divided into OVX group (n = 14), low-dose HE group (n = 14), middle-dose HE group (n = 14), high-dose HE group (n = 14) and positive group (n = 14). The BMD was measured by dual-energy X-ray. The microstructure of the bone was observed by micro‑computed tomography. Results Twelve weeks after ovariectomy, the BMD of femur of rats in OVX group was significantly lower than that of in sham group (P < 0.05). After 12 weeks of treatment, the BMD of femurs of rats in HE and positive groups were significantly higher than that in OVX group (P < 0.05), also the bone microstructure of rats in HE group has been recovered as the positive group. Conclusion HE has strong therapeutical effect on OP, can improve the BMD and microstructure of bones.
Authors and Affiliations
Ronghua Zhang et al.
Keywords
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