EFFECT OF HPMC 4 CPS AND CARBOPOL 974P NF ON RELEASE KINETICS OF<br /> CIPROFLOXACIN FROM KOLLIDON® SR EMBEDDED MATRIX TABLETS
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 4
Abstract
Controlled release (CR) Ciprofloxacin (CFX) matrix tablets were prepared using Ciprofloxacin betaine as a model drug and Kollidon® SR as a core matrix former. Kollidon® SR embedded CFX matrix tablets were then characterized with Carbopol 974P NF, Cetyl alcohol, Hydroxypropyl methyl cellulose (HPMC 4.5 cps). CFX release was 74% after 10 hours dissolution in 0.01 N HCl solution from the tablets containing only Kollidon® SR. Though addition of only HPMC 4.5 cps increased the release rate of CFX, combination of HPMC 4.5 cps, cetyl alcohol and Carbopol 974P NF, Cetyl alcohol decreased the release rate of CFX. The increased released rate of CFX from the former formulations might be due to the hydrophilic nature of HPMC 4.5 cps and the reduced CFX release from the latter formulations might be due to the hydrophobic and release retarding nature of Carbopol 974P NF and Cetyl alcohol. Highest MDT value and lowest release rate was 13.54 hour and 14.21 %hr-0.5 respectively for 9% Carbopol 974P NF-18% cetyl alcohol containing tablet. Whereas lowest MDT value and highest release rate was 4.7 hour and 28.48 %hr-0.5 respectively for 27% HPMC 4.5 cps-0% cetyl alcohol containing tablet. CR tablets of CFX followed non-Fickian or anomalous type release. But, polymer relaxation dominated more on CFX release than diffusion from HPMC containing tablets (n were nearer to 0.7) whereas diffusion dominated more on CFX release than polymer relaxation from Carbopol containing tablets (n were nearer to 0.6).
Authors and Affiliations
Md. Asaduzzaman , Md. Saiful Islam , Reza-ul Jalil , Md. Elias-Al-Mamun
Keywords
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