Effect of Hydroalcoholic extract of Baliospermum montanum roots against diabetic nephropathy on rats.
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2013, Vol 2, Issue 1
Abstract
Baliospermummontanum is a plant possessing medicinal properties. The test sample was prepared by extracting the material using Soxhlet apparatus taking ethanol and water in 7:3 ratio. In this study, the anti-diabetic effect on oral administration of hydro alcoholic extract of Baliospermummontanum plant root at the dose of 100mg/kg, 200mg/kg on Streptozotocin (STZ) induced diabetic rats has been studied. The treatment was assessed by measuring the blood glucose levels for once in three weeks. The extract was given continuously for 40 days. Then at the 39th day urine was collected by placing the rats in metabolic cages for 24 hours. Then on 40th day blood samples were collected from retro-orbital plexus. After collection of samples biochemical parameters like serum albumin, cholesterol, total protein, creatinine and blood urea nitrogen were measured using various kits with the help of semi auto analyser. The investigated results showed that the extract inhibited the STZ induced diabetes in a dose dependent manner and this effect was more significant with 200mg/kg dose. The reports showed that reduced blood glucose levels in the animals. And also serum levels of cholesterol, blood urea nitrogen, creatinine and urine samples albumin and total protein were also reduced. The results suggest that the hydro alcoholic extract of Baliospermummontanum at a dose of 200 mg/kg exhibits significant effect on diabetic nephropathy.
Authors and Affiliations
S. Mohanraghupathy S. Mohanraghupathy
Keywords
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