Effect of IEM 1460 – a selective antagonist of GluR2-lacking AMPA receptors – on the action of conventional antiepileptic drugs against maximal electroshock in mice
Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2007, Vol 1, Issue 1
Abstract
The objective of the study was to determine the effect of combined treatment with IEM-1460 (a selective GluR2-lacking, Ca[sup] 2+[/sup] permeable AMPA receptors) and conventional antiepileptic drugs: CBZ (carbamazepine), valproate (VPA), phenobarbital (PB), and phenytoin (PHT) against maximal electroshock-induced convulsions in mice. IEM-1460 (up to 30 mg/kg) did not show anticonvulsant action in the test for electroconvulsive threshold. The substance did not influence the antiseizure effectiveness of antiepileptic drugs. This may indicate that not all AMPA receptor antagonists may be useful as additive drugs in the complex therapy of epilepsy. On the other hand, the GluR2-lacking, Ca [sup]2+ [/sup]permeable subtype of AMPA receptors may be not crucial for seizure phenomena.
Authors and Affiliations
Kinga K. Borowicz, Monika Banach
Keywords
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