Effect of injection volume on clinical efficacy after minimally invasive puncture and drainage in the treatment of moderate basal ganglia cerebral hemorrhage underlying controlling the dosage of drugs in the elderly
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 5
Abstract
[Objective] To investigate the effect of injection volume on clinical efficacy after minimally invasive puncture and drainage in the treatment of moderate basal ganglia cerebral hemorrhage underlying controlling the dosage of drugs in the elderly. [Methods] After successfully inserting the puncture needle into the center point in the largest layer long axis, the liquid hematoma was aspirated, and 40,000 units urokinase was injected into the hematoma cavity twice a day(2 mL in the small volume Group (SG), and 4 mL in the large volume group(LG), respectively). The needle were then adjusted and removed according to the hematoma clearance. The clearance rate of hematoma, intracranial pressure, edema volume, mortality, incidence of complications, neurological deficit score (NDS) and activities of daily living (ADL) were compared and analyzed. [Results] There were no significant differences in the first hematoma clearance rate, postoperative ICP and mortality between the two groups (P>0.05). Comparing to the SG, there was a relative higher postoperative hematoma clearance rate and lower volume of perihematoma edema in the LG (P < 0.05). Meanwhile, the needle retention time, urokinase usage and cumulative complications at 28 days after operation were lower than in the SG( P<0.05). For two parameters representing long-term outcome, the NDS and ADL scores were much better in LG than in SG (P<0.05). [Conclusion] Large volume injection can effectively drain the hematoma, shorten the needle retention time, reduce the usage of urokinase, decrease the incidence of postoperative complications and improve the prognosis of patients, thereby providing effective and safe method in treating moderate basal ganglia cerebral hemorrhage in the elderly.
Authors and Affiliations
Liang WANG, Wei DONG, Lian ZHENG, Jinmiao ZHANG, Ding YUAN, Guo. CHENG
Keywords
Related Articles
- EP ID EP750500
- DOI 10.3969/j.issn.1002-0152.2024.05.003
- Views 28
- Downloads 0
A study on the correlation between childhood trauma, resilience and non-suicidal self-injury in adolescents
[Objective] To explore association between childhood trauma, resilience and non-suicidal self-injury in adolescents. [Methods] One hundred and fifty-eight first-episode adolescent patients with mood disorders were select...
The correlation between cerebral perfusion and auditory cognitive ability in patients with amnestic mild cognitive impairment
[Objective] To explore the correlation between changes in cerebral blood flow and auditory cognitive function in patients with amnestic mild cognitive impairment (aMCI). [Methods] The aMCI patients who visited the Memory...
Clinical analysis of patients with SARS-CoV-2 encephalitis confirmed by next-generation sequencing of cerebrospinal fluid
[Objective] To explore the clinical features, diagnostic methods, and treatment strategies for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encephalitis confirmed through cerebrospinal fluid (CSF) analysi...
A case of spinocerebellar ataxia type 8 presenting with multiple system atrophy cerebral type
We report a case of spinocerebellar ataxia type 8 (SCA8) presenting with multisystem atrophic phenotype. The patient was a 57-year-old male with a 4-year course of illness with dizziness and ataxia as the first symptoms,...
Effect of injection volume on clinical efficacy after minimally invasive puncture and drainage in the treatment of moderate basal ganglia cerebral hemorrhage underlying controlling the dosage of drugs in the elderly
[Objective] To investigate the effect of injection volume on clinical efficacy after minimally invasive puncture and drainage in the treatment of moderate basal ganglia cerebral hemorrhage underlying controlling the dosa...